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Research ArticleResearch Article: New Research, Cognition and Behavior

Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition

Cheng-Long Yu, Jin-Nan Li, Ping Gan, Li-Ping Wang, Yue-Xiong Yang, Da-Fu Yu, Rong-Rong Mao, Fu-Qiang Xu, Qi-Xin Zhou, Gal Richter-Levin, Lin Xu and Heng Zhou
eNeuro 30 March 2021, 8 (2) ENEURO.0398-20.2021; https://doi.org/10.1523/ENEURO.0398-20.2021
Cheng-Long Yu
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
6The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
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Jin-Nan Li
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Ping Gan
2Department of Biochemistry and Molecular Biology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, China
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Li-Ping Wang
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Yue-Xiong Yang
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Da-Fu Yu
3Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, and Key Laboratory of Medical Imaging, Kunming University of Science and Technology, Kunming 650032, China
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Rong-Rong Mao
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Fu-Qiang Xu
4Wuhan Institute of Physics and Mathematics, CAS, Wuhan 430071, China
6The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
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  • ORCID record for Fu-Qiang Xu
Qi-Xin Zhou
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Gal Richter-Levin
5Department of Neurobiology and Ethology, and Department of Psychology, University of Haifa, Haifa 3498838, Israel
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Lin Xu
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Heng Zhou
1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0398-20.2021
PubMed 
33785521
Published By 
Society for Neuroscience
History 
  • Received September 15, 2020
  • Revision received March 17, 2021
  • Accepted March 18, 2021
  • Published online March 30, 2021.
Copyright & Usage 
Copyright © 2021 Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Cheng-Long Yu1,6,*,
  2. Jin-Nan Li1,*,
  3. Ping Gan2,
  4. Li-Ping Wang1,
  5. Yue-Xiong Yang1,
  6. Da-Fu Yu3,
  7. Rong-Rong Mao1,
  8. Fu-Qiang Xu4,6,
  9. Qi-Xin Zhou1,
  10. Gal Richter-Levin5,
  11. Lin Xu1 and
  12. Heng Zhou1
  1. 1Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China
  2. 2Department of Biochemistry and Molecular Biology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, China
  3. 3Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, and Key Laboratory of Medical Imaging, Kunming University of Science and Technology, Kunming 650032, China
  4. 4Wuhan Institute of Physics and Mathematics, CAS, Wuhan 430071, China
  5. 5Department of Neurobiology and Ethology, and Department of Psychology, University of Haifa, Haifa 3498838, Israel
  6. 6The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
  1. Correspondence should be addressed to Heng Zhou at xuanfengheng{at}163.com or Lin Xu at lxu{at}vip.163.com.
  • H. Zhou’s present address: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA.

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Author contributions

  1. Author contributions: C.-L.Y., J.-N.L., R.-R.M., F.-Q.X., G.R.-L., L.X., and H.Z. designed research; C.-L.Y., J.-N.L., L.-P.W., D.-F.Y., and H.Z. performed research; J.-N.L., P.G., L.-P.W., Y.-X.Y., D.-F.Y., R.-R.M., F.-Q.X., Q.-X.Z., G.R.-L., and H.Z. contributed unpublished reagents/analytic tools; C.-L.Y., J.-N.L., P.G., Y.-X.Y., D.-F.Y., Q.-X.Z., and H.Z. analyzed data; P.G., F.-Q.X., Q.-X.Z., G.R.-L., L.X., and H.Z. wrote the paper.

  2. ↵* C.-L.Y. and J.-N.L. contributed equally to this work.

  • H. Zhou’s present address: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Natural Science Foundation of China Grants 31100775 and 31371141 (to Q.-X.Z.), U15022058 (to L.X.), 31860272 (to P.G.), and 31861143037 (to L.X. and G.R.-L.); the Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB32020000 (to L.X.); the Department of Science and Technology Program of Yunnan Province Grant 2016HA002 (to L.X.); the External Cooperation Program BIC of the Chinese Academy of Sciences Grant GJHZ1549 (to G.R.-L.); and the Youth Innovation Promotion Association of the Chinese Academy of Sciences Grant 2013250 (to Q.-X.Z.).

Funding

  • National Natural Science Foundation of China (NSFC)

    31100775; 31371141; U15022058; 31860272; 31861143037
  • Strategic Priority Research Program of the Chinese Academy of Sciences

    XDB32020000
  • Department of Science and Technology Programe of Yunnan Province

    2016HA002
  • External Cooperation Progam BIC of the Chinese Academy of Sciences

    GJHZ1549
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences (Youth Innovation Promotion Association CAS)

    2013250

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 30, 2021).

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AbstractFullPdf
Mar 202137011
Apr 2021442147154
May 202112431549
Jun 20214120518
Jul 20211818715
Aug 2021221929
Sep 20211011723
Oct 20211512547
Nov 202159731
Dec 202139425
Total 20217171479382
Jan 2022411114
Feb 20223568
Mar 202276110
Apr 202227010
May 202259110
Jun 202249012
Jul 202235310
Aug 20224459
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Total 202241749126
Jan 202305911
Feb 202315813
Mar 202335412
Apr 20233658
May 20230639
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Jul 202327616
Aug 202356319
Sep 20235657
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Total 202332812138
Jan 20243727
Feb 202476811
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Apr 20241233512
May 202457612
Jun 202497614
Jul 202437116
Aug 2024119814
Sep 202448010
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Total 2024641208123
Jan 202598512
Feb 202511047
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Apr 2025510312
May 20253895
Jun 202568513
Jul 202579421
Aug 2025108523
Sep 2025513811
Oct 20256959
Nov 20251111911
Dec 20251414028
Total 2025821212167
Jan 20261414411
Feb 202661332
Total 20262027713
Total9565737949
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Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition
Cheng-Long Yu, Jin-Nan Li, Ping Gan, Li-Ping Wang, Yue-Xiong Yang, Da-Fu Yu, Rong-Rong Mao, Fu-Qiang Xu, Qi-Xin Zhou, Gal Richter-Levin, Lin Xu, Heng Zhou
eNeuro 30 March 2021, 8 (2) ENEURO.0398-20.2021; DOI: 10.1523/ENEURO.0398-20.2021

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Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition
Cheng-Long Yu, Jin-Nan Li, Ping Gan, Li-Ping Wang, Yue-Xiong Yang, Da-Fu Yu, Rong-Rong Mao, Fu-Qiang Xu, Qi-Xin Zhou, Gal Richter-Levin, Lin Xu, Heng Zhou
eNeuro 30 March 2021, 8 (2) ENEURO.0398-20.2021; DOI: 10.1523/ENEURO.0398-20.2021
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Keywords

  • amygdala
  • circuits
  • fear memory
  • hippocampus
  • ischemia

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