Input conductance | 0.42 ± 0.16 μS [0.35–0.49] | 0.72 ± 0.18 μS [0.64–0.82] | 1.73 [0.93–2.40] (p = 2.2e −05****) | 0.46 ± 0.16 μS [0.39–0.54] | 0.42 ± 0.15 μS [0.36–0.48] | −0.28 [−0.96–0.39] (p = 0.39) | 0.60 ± 0.15 μS [0.53–0.67] | 0.33 ± 0.13 μS [0.26–0.39] | −1.85 [−2.57–−1.17] (p = 2.1e −05****) |
PIC amplitude | 2.30 ± 2.17 nA [1.52–3.45] | 6.73 ± 3.28 nA [5.18–8.51] | 1.59 [0.62–2.48] (p = 0.00016***) | 2.47 ± 1.69 nA [1.81–3.51] | 2.75 ± 2.40 nA [1.97–3.89] | 0.12 [−0.53–0.67] (p = 0.67) | 4.12 ± 3.69 nA [2.67–6.40] | 1.90 ± 1.78 nA [1.24–3.19] | −0.74 [−1.27–0.00] (p = 0.05) |
PIC amplitude (down ramp) | 2.65 ± 2.60 nA [1.76–4.16] | 5.55 ± 3.48 nA [4.01–7.45] | 0.94 [0.15–1.70] (p = 0.013*) | 2.29 ± 2.30 nA [1.52–4.01] | 2.87 ± 2.22 nA [2.12–3.87] | 0.25 [−0.50–0.82] (p = 0.44) | 4.43 ± 3.10 nA [3.03–6.09] | 2.25 ± 1.98 nA [1.48–3.56] | −0.81 [−1.49–−0.03] (p = 0.032*) |
Current at transition SPR/PR | 5.93 ± 3.24 nA [4.37–8.51] | 8.01 ± 2.67 nA [6.54–9.24] | 0.69 [−0.48–1.68] (p = 0.13) | 6.28 ± 3.92 nA [4.32–9.67] | 5.23 ± 3.30 nA [3.99–7.23] | −0.29 [−1.34–0.48] (p = 0.53) | 5.90 ± 2.70 nA [4.24–7.38] | 2.70 ± 2.34 nA [1.18–3.76] | −1.23 [−2.07–−0.35] (p = 0.0081**) |
Recruitment current | 4.73 ± 3.14 nA [3.50–6.23] | 6.21 ± 2.51 nA [4.77–7.27] | 0.50 [−0.25–1.26] (p = 0.14) | 5.28 ± 2.64 nA [4.19–6.79] | 4.53 ± 3.38 nA [3.35–6.35] | −0.24 [−0.94–0.43] (p = 0.46) | 5.43 ± 3.07 nA [4.07–7.16] | 2.19 ± 1.56 nA [1.59–3.32] | −1.26 [−1.96–−0.52] (p = 0.0017**) |
Current at de- recruitment | 5.92 ± 3.76 nA [4.38–7.65] | 7.64 ± 3.31 nA [5.91–9.24] | 0.47 [−0.24–1.19] (p = 0.17) | 6.54 ± 4.07 nA [4.69–9.12] | 5.01 ± 4.05 nA [3.54–7.04] | −0.37 [−1.16–0.33] (p = 0.31) | 5.64 ± 2.95 nA [4.03–7.22] | 2.59 ± 1.58 nA [1.93–3.64] | −1.26 [−2.23–−0.37] (p = 0.0056**) |
Frequency at transition SPR/PR | 54.30 ± 17.35 Hz [45.49–66.17] | 57.90 ± 17.06 Hz [49.74–66.74] | 0.20 [−0.65–1.04] (p = 0.62) | 53.55 ± 13.32 Hz [44.57–62.21] | 43.75 ± 13.55 Hz [36.99–49.60] | −0.70 [−1.52–0.09] (p = 0.11) | 51.58 ± 15.41 Hz [41.70–59.94] | 42.44 ± 11.34 Hz [36.74–48.89] | −0.67 [−1.58–0.23] (p = 0.13) |
Normalized PIC amplitude (down ramp) | 6.72 ± 5.77 nA/μS [4.50–9.57] | 7.85 ± 4.85 nA/μS [5.49–10.58] | 0.20 [−0.48–0.96] (p = 0.56) | 5.05 ± 4.43 nA/μS [3.38–7.73] | 6.81 ± 5.14 nA/μS [5.24–9.34] | 0.35 [−0.35–0.89] (p = 0.26) | 7.77 ± 5.24 nA/μS [5.46–10.56] | 6.72 ± 4.91 nA/μS [4.77–9.82] | −0.20 [−0.92–0.60] (p = 0.58) |
ΔI (current at de- recruitment− recruitment) | 1.20 ± 1.20 nA [0.69–1.74] | 1.45 ± 1.25 nA [0.89–2.17] | 0.20 [−0.49–0.87] (p = 0.57) | 1.47 ± 1.83 nA [0.57–2.52] | 0.42 ± 1.10 nA [−0.01–0.94] | −0.72 [−1.57–0.05] (p = 0.093) | 0.98 ± 1.32 nA [0.38–1.78] | 0.39 ± 0.63 nA [0.05–0.71] | −0.55 [−1.28–0.27] (p = 0.18) |
Voltage threshold (relative to RMP) | 17.03 ± 6.37 mV [14.16–19.76] | 18.09 ± 5.21 mV [15.10–20.44] | 0.17 [−0.53–0.86] (p = 0.61) | 15.59 ± 5.54 mV [13.26–18.55] | 19.26 ± 6.29 mV [16.80–22.24] | 0.60 [−0.13–1.26] (p = 0.072) | 17.10 ± 5.54 mV [14.32–19.66] | 13.79 ± 3.62 mV [12.09–15.77] | −0.67 [−1.44–0.15] (p = 0.071) |
ΔF (frequency at de- recruitment− recruitment) | 1.79 ± 13.96 Hz [−5.29–7.01] | 3.77 ± 11.06 Hz [−1.51–9.55] | 0.15 [−0.56–0.80] (p = 0.65) | 6.53 ± 17.29 Hz [0.25–21.46] | 1.93 ± 8.73 Hz [−1.51–6.16] | −0.36 [−1.12–0.37] (p = 0.4) | −0.85 ± 7.97 Hz [−4.64–4.12] | 0.75 ± 7.97 Hz [−3.66–4.64] | 0.19 [−0.66–1.04] (p = 0.62) |
PIC peak voltage (relative to RMP) | 18.32 ± 7.08 mV [15.26–21.42] | 19.13 ± 8.15 mV [14.28–22.51] | 0.10 [−0.61–0.82] (p = 0.76) | 18.09 ± 7.71 mV [15.11–22.59] | 21.18 ± 5.82 mV [19.14–23.99] | 0.45 [−0.34–1.10] (p = 0.19) | 16.37 ± 8.32 mV [12.41–20.31] | 15.60 ± 5.86 mV [12.55–18.63] | −0.10 [−0.87–0.66] (p = 0.78) |
F-I gain (PR, descending ramp) | 19.21 ± 10.07 Hz/nA [15.19–29.17] | 17.23 ± 5.15 Hz/nA [14.91–20.03] | −0.25 [−1.15–0.58] (p = 0.58) | 33.93 ± 35.75 Hz/nA [18.24–75.19] | 15.25 ± 8.95 Hz/nA [11.99–21.30] | −0.88 [−1.69–0.11] (p = 0.22) | 15.15 ± 7.14 Hz/nA [11.73–20.87] | 20.05 ± 11.30 Hz/nA [15.50–28.05] | 0.48 [−0.48–1.07] (p = 0.23) |
F-I gain (PR, ascending ramp) | 9.30 ± 3.58 Hz/nA [7.08–11.31] | 8.30 ± 3.37 Hz/nA [6.42–9.86] | −0.28 [−1.09–0.63] (p = 0.5) | 12.18 ± 7.30 Hz/nA [8.81–19.47] | 10.28 ± 6.43 Hz/nA [8.15–15.26] | −0.27 [−1.23–0.53] (p = 0.54) | 8.01 ± 3.16 Hz/nA [6.33–10.08] | 10.84 ± 9.13 Hz/nA [7.69–19.20] | 0.38 [−0.41–0.94] (p = 0.31) |
PIC onset voltage (relative to RMP) | 4.36 ± 5.66 mV [1.69–6.68] | 2.05 ± 5.38 mV [−1.02–4.23] | −0.41 [−1.05–0.28] (p = 0.23) | 1.76 ± 5.75 mV [−0.85–4.65] | 6.12 ± 5.54 mV [3.80–8.38] | 0.76 [0.01–1.40] (p = 0.025*) | 1.57 ± 5.10 mV [−0.86–4.11] | 0.92 ± 5.94 mV [−1.76–4.48] | −0.11 [−0.93–0.64] (p = 0.76) |
Resting membrane potential | −62.38 ± 5.52 mV [−64.71–−59.91] | −71.45 ± 8.78 mV [−75.13–−66.37] | −1.24 [−2.19–−0.28] (p = 0.002**) | −60.98 ± 5.35 mV [−63.81–−58.71] | −66.18 ± 5.63 mV [−68.56–−63.88] | −0.92 [−1.54–−0.19] (p = 0.0067**) | −64.71 ± 7.42 mV [−68.61–−61.39] | −61.99 ± 5.43 mV [−64.41–−58.61] | 0.40 [−0.32–1.10] (p = 0.27) |
Voltage threshold for spiking | −45.35 ± 5.48 mV [−47.79–−43.03] | −54.86 ± 5.15 mV [−57.21–−52.17] | −1.74 [−2.53–−0.84] (p = 1.9e −05****) | −45.39 ± 7.04 mV [−49.10–−42.26] | −47.53 ± 5.85 mV [−49.76–−44.73] | −0.33 [−1.04–0.38] (p = 0.34) | −47.61 ± 5.00 mV [−49.94–−45.17] | −48.20 ± 5.41 mV [−50.94–−45.31] | −0.11 [−0.85–0.63] (p = 0.77) |
PIC peak voltage | −43.83 ± 4.79 mV [−45.74–−41.49] | −52.32 ± 4.20 mV [−54.10–−50.00] | −1.83 [−2.60–−1.03] (p = 4.8e −06****) | −42.89 ± 6.94 mV [−45.81–−39.26] | −44.88 ± 5.24 mV [−46.93–−42.88] | −0.33 [−0.97–0.33] (p = 0.34) | −48.34 ± 5.89 mV [−50.89–−45.11] | −46.24 ± 6.27 mV [−49.56–−43.26] | 0.34 [−0.43–1.15] (p = 0.36) |
PIC onset voltage | −58.03 ± 6.35 mV [−60.91–−55.34] | −69.41 ± 5.71 mV [−71.66–−66.01] | −1.83 [−2.69–−0.81] (p = 5.1e−06****) | −59.22 ± 4.88 mV [−61.96–−57.18] | −59.66 ± 6.39 mV [−61.98–−56.91] | −0.07 [−0.70–0.54] (p = 0.81) | −63.15 ± 6.31 mV [−65.99–−59.85] | −60.12 ± 7.25 mV [−63.92–−56.48] | 0.43 [−0.35–1.17] (p = 0.24) |
PIC end voltage | −58.67 ± 6.87 mV [−61.68–−55.65] | −71.37 ± 6.36 mV [−73.99–−67.60] | −1.86 [−2.69–−0.80] (p = 4.1e−06****) | −60.48 ± 4.90 mV [−63.57–−58.66] | −61.80 ± 7.27 mV [−64.75–−58.95] | −0.20 [−0.77–0.42] (p = 0.5) | −65.00 ± 5.70 mV [−67.79–−62.19] | −61.30 ± 8.12 mV [−65.34–−57.16] | 0.52 [−0.28–1.27] (p = 0.17) |
PIC peak voltage (down ramp) | −43.73 ± 4.89 mV [−45.62–−41.28] | −53.63 ± 4.90 mV [−55.76–−50.95] | −1.97 [−2.78–−1.17] (p = 2.1e−06****) | −42.49 ± 8.15 mV [−45.71–−37.94] | −45.85 ± 6.11 mV [−48.41–−43.56] | −0.47 [−1.08–0.16] (p = 0.17) | −48.14 ± 5.25 mV [−50.45–−45.05] | −45.98 ± 6.26 mV [−49.54–−43.13] | 0.37 [−0.41–1.20] (p = 0.32) |