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- Page navigation anchor for Safe clinical application of TPS (Transcranial Pulse Stimulation) high pressure Focused Ultrasound pulsesSafe clinical application of TPS (Transcranial Pulse Stimulation) high pressure Focused Ultrasound pulses
This highly interesting study by Collins et al. provides profound evidence that low pressure ultrasound pulses applied over longer trains of several hundred milliseconds may generate neuromodulatory effects via local heating. Such effects will have to be considered when it comes to first clinical studies with long train Focused Ultrasound (FUS) in larger patient cohorts. In clarification and extension of the authors discussion, it is important to note that the novel ultrashort ultrasound application TPS (Transcranial Pulse Stimulation, Beisteiner et al., 2019) is based on a completely different high pressure technique. TPS already is in safe and broad clinical application. Precisely navigated TPS uses high pressure but very short ultrasound pulses (0.003 ms duration) and studies with larger patient cohorts are already available. They demonstrate cognitive improvement in Alzheimer’s patients and associated cortical thickness increases of their default mode network areas (Popescu et al., 2020). Despite the short time from first TPS description (end of 2019) several clinical centers meanwhile apply and research TPS worldwide. Within our pioneering consortium safety experience is now available from more than 2000 patient applications. With highly localized pulse pressures up to 25 MPa, the international clinical neuromodulation experience indicates that treatments with TPS pulses are safe. Comprehensive laboratory and animal studies indicate that below 40 MPa serious adverse e...
Show MoreCompeting Interests: None declared.