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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons

Hirotaka Watanabe, Kent Imaizumi, Tetsuo Cai, Zhi Zhou, Taisuke Tomita and Hideyuki Okano
eNeuro 19 February 2021, 8 (2) ENEURO.0500-20.2021; https://doi.org/10.1523/ENEURO.0500-20.2021
Hirotaka Watanabe
1Department of Physiology, Keio University, School of Medicine, Tokyo 160-8582, Japan
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Kent Imaizumi
1Department of Physiology, Keio University, School of Medicine, Tokyo 160-8582, Japan
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Tetsuo Cai
2Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
3Research Fellow of Japan Society for the Promotion of Science (JSPS), Tokyo 102-0083, Japan
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Zhi Zhou
1Department of Physiology, Keio University, School of Medicine, Tokyo 160-8582, Japan
3Research Fellow of Japan Society for the Promotion of Science (JSPS), Tokyo 102-0083, Japan
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Taisuke Tomita
2Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
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Hideyuki Okano
1Department of Physiology, Keio University, School of Medicine, Tokyo 160-8582, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0500-20.2021
PubMed 
33608391
Published By 
Society for Neuroscience
History 
  • Received November 21, 2020
  • Revision received January 27, 2021
  • Accepted January 30, 2021
  • Published online February 19, 2021.
Copyright & Usage 
Copyright © 2021 Watanabe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hirotaka Watanabe1,
  2. Kent Imaizumi1,
  3. Tetsuo Cai2,3,
  4. Zhi Zhou1,3,
  5. Taisuke Tomita2 and
  6. Hideyuki Okano1
  1. 1Department of Physiology, Keio University, School of Medicine, Tokyo 160-8582, Japan
  2. 2Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
  3. 3Research Fellow of Japan Society for the Promotion of Science (JSPS), Tokyo 102-0083, Japan
  1. Correspondence should be addressed to Hirotaka Watanabe at hwatanabe{at}keio.jp or Hideyuki Okano at hidokano{at}keio.jp.
View Full Text

Author contributions

  1. Author contributions: H.W. designed research; H.W., K.I., and T.C. performed research; Z.Z., T.T., and H.O. contributed unpublished reagents/analytic tools; H.W. and K.I. analyzed data; H.W. wrote the paper.

Disclosures

  • H.O. is a scientific consultant for SanBio, Co. Ltd., and K Pharma Inc. All other authors declare no competing financial interests.

  • This work was supported by Japan Society for the Promotion of Science KAKENHI Grants 15H06587 and 17K08668 (to H.W.) and 19H01015 (to T.T.); Research Project for Practical Applications of Regenerative Medicine from the Japan Agency for Medical Research and Development (AMED) Grants 15bk0104027h0003, 16bk0104016h0004, and 17bk0104016h0005 (to H.O.); the Research Center Network for Realization Research Centers/Projects of Regenerative Medicine (the Program for Intractable Disease Research Utilizing Disease-specific iPS Cells and the Acceleration Program for Intractable Diseases Research Utilizing Disease-specific iPS Cells) from AMED (Grants 15bm0609003h0004, 16bm0609003h0005, 17bm0804003h0001, 18bm0804003h0002, 19bm0804003h0003, and 20bm0804003h0104; to H.O.); and the Program for Initiative Research Projects from Keio University to H.O.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    15H06587; 17K08668; 19H01015
  • Japan Agency for Medical Research and Development (AMED)

    15bk0104027h0003; 16bk0104016h0004; 17bk0104016h0005; 15bm0609003h0004; 16bm0609003h0005; 17bm0804003h0001; 18bm0804003h0002; 19bm0804003h0003; 20bm0804003h0104

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 19, 2021).

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Total 2025851347285
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Total 20263797
Total137767681466
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Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
Hirotaka Watanabe, Kent Imaizumi, Tetsuo Cai, Zhi Zhou, Taisuke Tomita, Hideyuki Okano
eNeuro 19 February 2021, 8 (2) ENEURO.0500-20.2021; DOI: 10.1523/ENEURO.0500-20.2021

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Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
Hirotaka Watanabe, Kent Imaizumi, Tetsuo Cai, Zhi Zhou, Taisuke Tomita, Hideyuki Okano
eNeuro 19 February 2021, 8 (2) ENEURO.0500-20.2021; DOI: 10.1523/ENEURO.0500-20.2021
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Keywords

  • γ-secretase
  • β-amyloid
  • iPSC
  • presenilin

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