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Research ArticleResearch Article: New Research, Neuronal Excitability

Noradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway

Maria Jesus Valero-Aracama, Antonio Reboreda, Alberto Arboit, Magdalena Sauvage and Motoharu Yoshida
eNeuro 26 February 2021, 8 (2) ENEURO.0440-20.2020; https://doi.org/10.1523/ENEURO.0440-20.2020
Maria Jesus Valero-Aracama
1Faculty of Psychology, Mercator Research Group-Structure of Memory, Ruhr-University Bochum, Bochum 44780, Germany
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Antonio Reboreda
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
3Leibniz Institute for Neurobiology (LIN), Magdeburg 39118, Germany
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Alberto Arboit
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
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Magdalena Sauvage
3Leibniz Institute for Neurobiology (LIN), Magdeburg 39118, Germany
4Otto von Guericke University, Functional Neuroplasticity, Medical Faculty, Magdeburg 39120, Germany
5Center for Behavioral Brain Sciences (CBBS), 39106, Magdeburg, Germany
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Motoharu Yoshida
1Faculty of Psychology, Mercator Research Group-Structure of Memory, Ruhr-University Bochum, Bochum 44780, Germany
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
3Leibniz Institute for Neurobiology (LIN), Magdeburg 39118, Germany
5Center for Behavioral Brain Sciences (CBBS), 39106, Magdeburg, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0440-20.2020
PubMed 
33637539
Published By 
Society for Neuroscience
History 
  • Received October 12, 2020
  • Revision received December 3, 2020
  • Accepted December 20, 2020
  • Published online February 26, 2021.
Copyright & Usage 
Copyright © 2021 Valero-Aracama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Maria Jesus Valero-Aracama1,*,
  2. Antonio Reboreda2,3,*,
  3. Alberto Arboit2,
  4. Magdalena Sauvage3,4,5 and
  5. Motoharu Yoshida1,2,3,5
  1. 1Faculty of Psychology, Mercator Research Group-Structure of Memory, Ruhr-University Bochum, Bochum 44780, Germany
  2. 2German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
  3. 3Leibniz Institute for Neurobiology (LIN), Magdeburg 39118, Germany
  4. 4Otto von Guericke University, Functional Neuroplasticity, Medical Faculty, Magdeburg 39120, Germany
  5. 5Center for Behavioral Brain Sciences (CBBS), 39106, Magdeburg, Germany
  1. Correspondence should be addressed to Motoharu Yoshida at motoharu.yoshida{at}lin-magdeburg.de.
  • M. J. Valero-Aracama’s present address: Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, 91054, Germany.

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Author contributions

  1. Author contributions: M.J.V.-A., A.R., M.S., and M.Y. designed research; M.J.V.-A., A.R., and A.A. performed research; M.J.V.-A., A.R., and A.A. analyzed data; M.J.V.-A., A.R., and M.Y. wrote the paper.

  2. ↵* M.J.V.-A. and A.R. contributed equally to this work.

  • M. J. Valero-Aracama’s present address: Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, 91054, Germany.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Mercator Stiftung and by German Research Foundation (DFG) Project Grants YO177/4-1 and YO177/7-1.

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    YO177/4-1; YO177/7-1
  • Mercator Stiftung

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 26, 2021).

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Total113146881095
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Noradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway
Maria Jesus Valero-Aracama, Antonio Reboreda, Alberto Arboit, Magdalena Sauvage, Motoharu Yoshida
eNeuro 26 February 2021, 8 (2) ENEURO.0440-20.2020; DOI: 10.1523/ENEURO.0440-20.2020

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Noradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway
Maria Jesus Valero-Aracama, Antonio Reboreda, Alberto Arboit, Magdalena Sauvage, Motoharu Yoshida
eNeuro 26 February 2021, 8 (2) ENEURO.0440-20.2020; DOI: 10.1523/ENEURO.0440-20.2020
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Keywords

  • β1 adrenoceptors
  • cAMP
  • M1 receptor
  • M2/4 receptors
  • persistent firing
  • PKA

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