Figure 3. Disc1 svΔ2 behavioral endophenotypes reinforce patterns of sex-specific alteration in neural microstructure. A, Mean duration in open arms of the elevated-plus maze (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant effect of genotype (F(1,39) = 8.081, p = 0.007). Mean duration was significantly shorter in Disc1 svΔ2 males versus wild-type males (p = 0.007), denoted by *. Mean duration was significantly shorter in Disc1 svΔ2 males versus Disc1 svΔ2 females (p = 0.032), denoted by #. B, Mean frequency in open arms of the elevated-plus maze (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant effect of genotype (F(1,39) = 5.476, p = 0.025). Mean frequency was significantly lower in Disc1 svΔ2 males versus wild-type males (p = 0.008), denoted by *. Mean frequency was significantly lower in Disc1 svΔ2 males versus Disc1 svΔ2 females (p = 0.013), denoted by #. C, Mean alternation percentage in the y-maze (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant effect of sex (F(1,39) = 4.875, p = 0.033) and genotype × sex interaction (F(1,39) = 5.620, p = 0.023). Mean alternation percentage was significantly lower in Disc1 svΔ2 males versus wild-type males (p = 0.005), denoted by *. Mean alternation percentage was significantly lower in Disc1 svΔ2 males versus Disc1 svΔ2 females (p = 0.002), denoted by #. D, Mean open field velocity (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant effect of genotype (F(1,39) = 9.125, p = 0.004), sex (F(1,39) = 7.003, p = 0.012), and genotype × sex interaction (F(1,39) = 15.65, p < 0.001). Mean velocity was significantly higher in Disc1 svΔ2 males versus wild-type males (p < 0.001), denoted by *. E, Mean open field distance traveled (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant effect of genotype (F(1,39) = 9.134, p = 0.004), sex (F(1,39) = 7.000, p = 0.012), and genotype × sex interaction (F(1,39) = 15.71, p < 0.001). Mean distance traveled was significantly higher in Disc1 svΔ2 males versus wild-type males (p < 0.001), denoted by *. F, Mean open field time spent moving (±SEM) of wild-type male (n = 12), Disc1 svΔ2 male (n = 9), wild-type female (n = 12), and Disc1 svΔ2 female (n = 10) rats. There was a significant genotype × sex interaction (F(1,39) = 18.54, p < 0.001). Mean distance traveled was significantly higher in Disc1 svΔ2 males versus wild-type males (p < 0.001) and in Disc1 svΔ2 females versus wild-type females (p = 0.022), denoted by *.