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Research ArticleReview, Disorders of the Nervous System

Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau

Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev and Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; https://doi.org/10.1523/ENEURO.0418-20.2020
Syed Faraz Kazim
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Joon Ho Seo
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Riccardo Bianchi
2The Robert F. Furchgott Center for Neural and Behavioral Science, and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY 11203
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Chloe S. Larson
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Abhijeet Sharma
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Robert K. S. Wong
2The Robert F. Furchgott Center for Neural and Behavioral Science, and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY 11203
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Kirill Y. Gorbachev
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Ana C. Pereira
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
3Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0418-20.2020
PubMed 
33741601
Published By 
Society for Neuroscience
History 
  • Received September 22, 2020
  • Revision received December 2, 2020
  • Accepted December 18, 2020
  • Published online March 19, 2021.
Copyright & Usage 
Copyright © 2021 Kazim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Syed Faraz Kazim1,
  2. Joon Ho Seo1,
  3. Riccardo Bianchi2,
  4. Chloe S. Larson1,
  5. Abhijeet Sharma1,
  6. Robert K. S. Wong2,
  7. Kirill Y. Gorbachev1 and
  8. Ana C. Pereira1,3
  1. 1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  2. 2The Robert F. Furchgott Center for Neural and Behavioral Science, and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY 11203
  3. 3Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029
  1. Correspondence should be addressed to Ana C. Pereira at ana.pereira{at}mssm.edu.
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Author contributions

  1. Author contributions: S.F.K., J.H.S., R.B., C.S.L., A.S., R.K.S.W., K.Y.G., and A.C.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • A.C.P. is supported by National Institutes of Health Grants R01AG064020 and R01AG063819, the Paul B. Beeson Emerging Leaders Career Development Award in Aging K76AG054772, the BrightFocus Foundation, the DANA Foundation, the Alzheimer’s Drug Discovery Foundation, the Alzheimer’s Association, the Bernard L. Schwartz Award for Physician Scientist, and seed money from Icahn School of Medicine at Mount Sinai. S.F.K. was supported by a doctoral fellowship from Neural and Behavioral Science Program, School of Graduate Studies, State University of New York (SUNY) Downstate Medical Center and SUNY Downstate/New York State Institute for Basic Research (NYSIBR) Program in Developmental Neuroscience, when initial ideas related to the discussion and perspectives presented in manuscript were generated and a part of this review was written.

Funding

  • NIH

    R01AG064020; R01AG063819
  • Paul B. Beeson Emerging Leaders Career Development Award

    K76AG054772
  • The BrightFocus Foundation

  • The DANA Foundation

  • The Alzheimer's Drug Discovery Foundation

  • The Alzheimer's Association

  • The Bernard L. Schwartz Award for Physician Scientist

  • Seed money from Icahn School of Medicine at Mount Sinai

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 19, 2021).

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Total1876127243698
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Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev, Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; DOI: 10.1523/ENEURO.0418-20.2020

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Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev, Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; DOI: 10.1523/ENEURO.0418-20.2020
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  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Aβ Induces Neuronal Network Hyperexcitability in AD, Even before the Development of Plaques
    • The Role of tau in Neuronal Network Excitability: The Enhancement versus Suppression Conundrum
    • Perspectives on the Similar versus Divergent Roles of Aβ and tau in Neuronal Network Hyperexcitability in AD: Which One Has a Dominant Effect, Aβ or tau?
    • Future Directions and Concluding Remarks
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • amyloid β
  • neuronal excitability
  • seizures
  • tau

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