Research ArticleReview, Disorders of the Nervous System
Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev and Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; DOI: https://doi.org/10.1523/ENEURO.0418-20.2020
Syed Faraz Kazim
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Joon Ho Seo
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Riccardo Bianchi
2The Robert F. Furchgott Center for Neural and Behavioral Science, and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY 11203
Chloe S. Larson
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Abhijeet Sharma
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Robert K. S. Wong
2The Robert F. Furchgott Center for Neural and Behavioral Science, and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY 11203
Kirill Y. Gorbachev
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Ana C. Pereira
1Department of Neurology and Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
3Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029
In this issue
Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev, Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; DOI: 10.1523/ENEURO.0418-20.2020
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Neuronal Network Excitability in Alzheimer’s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev, Ana C. Pereira
eNeuro 19 March 2021, 8 (2) ENEURO.0418-20.2020; DOI: 10.1523/ENEURO.0418-20.2020
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- Article
- Abstract
- Significance Statement
- Introduction
- Aβ Induces Neuronal Network Hyperexcitability in AD, Even before the Development of Plaques
- The Role of tau in Neuronal Network Excitability: The Enhancement versus Suppression Conundrum
- Perspectives on the Similar versus Divergent Roles of Aβ and tau in Neuronal Network Hyperexcitability in AD: Which One Has a Dominant Effect, Aβ or tau?
- Future Directions and Concluding Remarks
- Acknowledgments
- Footnotes
- References
- Synthesis
- Figures & Data
- Info & Metrics
- eLetters
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