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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders

Caitlin Menzies, Shama Naz, David Patten, Thierry Alquier, Brian M. Bennett and Baptiste Lacoste
eNeuro 5 April 2021, 8 (2) ENEURO.0292-20.2021; https://doi.org/10.1523/ENEURO.0292-20.2021
Caitlin Menzies
1Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada
2Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
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Shama Naz
3University of Ottawa Metabolomics Core Facility, Faculty of Medicine, Ottawa, Ontario K1H 8M5, Canada
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David Patten
3University of Ottawa Metabolomics Core Facility, Faculty of Medicine, Ottawa, Ontario K1H 8M5, Canada
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Thierry Alquier
4Montreal Diabetes Research Center and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec H1W 4A4, Canada
5Department of Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada
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Brian M. Bennett
6Faculty of Health Sciences, Department of Biomedical and Molecular Sciences and Centre for Neuroscience Studies, Queens University, Kingston, Ontario K7L 3N6, Canada
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Baptiste Lacoste
1Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada
2Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
7University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario K1H 8M5, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0292-20.2021
PubMed 
33820803
Published By 
Society for Neuroscience
History 
  • Received July 3, 2020
  • Revision received February 27, 2021
  • Accepted March 15, 2021
  • Published online April 5, 2021.
Copyright & Usage 
Copyright © 2021 Menzies et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Caitlin Menzies1,2,
  2. Shama Naz3,
  3. David Patten3,
  4. Thierry Alquier4,5,
  5. Brian M. Bennett6 and
  6. Baptiste Lacoste1,2,7
  1. 1Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada
  2. 2Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
  3. 3University of Ottawa Metabolomics Core Facility, Faculty of Medicine, Ottawa, Ontario K1H 8M5, Canada
  4. 4Montreal Diabetes Research Center and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec H1W 4A4, Canada
  5. 5Department of Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada
  6. 6Faculty of Health Sciences, Department of Biomedical and Molecular Sciences and Centre for Neuroscience Studies, Queens University, Kingston, Ontario K7L 3N6, Canada
  7. 7University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario K1H 8M5, Canada
  1. Correspondence should be addressed to Baptiste Lacoste at blacoste{at}uottawa.ca.
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Author contributions

  1. Author contributions: B.L. and D.P. designed research; C.M. and D.P. performed research; B.M.B. contributed unpublished reagents/analytic tools; C.M., B.L., D.P., S.N., and T.A. analyzed data; C.M., B.M.B., B.L., D.P., S.N., and T.A. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Canadian Institutes of Health Research Grants 388805 (to B.L.) and 153013 (to B.M.B.) and by a Canadian Vascular Network Scholarship (C.M.). T.A. holds a salary Award from Fonds de Recherche Santé Québec. The Metabolomics Core Facility is supported by the Terry Fox Research Institute and the University of Ottawa.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    388805; 153013
  • Canadian Vascular Network

    Scholarship
  • Fonds de Recherche Sané Québec

    Award

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 05, 2021).

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Total 20251281545266
Jan 20261317518
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Total252077101844
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eneuro: 8 (2)
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Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders
Caitlin Menzies, Shama Naz, David Patten, Thierry Alquier, Brian M. Bennett, Baptiste Lacoste
eNeuro 5 April 2021, 8 (2) ENEURO.0292-20.2021; DOI: 10.1523/ENEURO.0292-20.2021

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Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders
Caitlin Menzies, Shama Naz, David Patten, Thierry Alquier, Brian M. Bennett, Baptiste Lacoste
eNeuro 5 April 2021, 8 (2) ENEURO.0292-20.2021; DOI: 10.1523/ENEURO.0292-20.2021
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Keywords

  • 16p11.2 deletion syndrome
  • basal metabolism
  • Down syndrome
  • fragile X syndrome
  • neurodevelopmental disorders
  • plasma metabolites

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