Extended Data Figure 3-1
Controls of ChR2-LFP recordings and measurement of ChR2-LFP slopes. A, Neuronal responses to optical stimulation is absent in brain region not expressing ChR2 (somatosensory cortex). B, Magnitude of ChR2-LFP increases with increase in laser power, keeping the duration of stimulation at 0.5 ms. C, The magnitude of ChR2-LFP increases if duration of stimulation is increased at the highest laser power of 0.980 mW. D, 30 min of slice incubation with 50 μμ CNQX abolishes the postsynaptic response of striatal neurons without affecting the depolarization of cortical fiber terminals in striatum (red) in comparison to predrug control (black). E, Example of normalized ChR2-LFP slope distribution in the left auditory striatum of an animal trained on the low-right contingency. F, Mean and SD of the normalized ChR2-slope data from E plotted along the tonotopic axis. Download Figure 3-1, TIF file.