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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Unique Effects of Social Defeat Stress in Adolescent Male Mice on the Netrin-1/DCC Pathway, Prefrontal Cortex Dopamine and Cognition

Philip Vassilev, Andrea Haree Pantoja-Urban, Michel Giroux, Dominique Nouel, Giovanni Hernandez, Taylor Orsini and Cecilia Flores
eNeuro 22 February 2021, 8 (2) ENEURO.0045-21.2021; https://doi.org/10.1523/ENEURO.0045-21.2021
Philip Vassilev
1Department of Psychiatry and Department of Neurology and Neurosurgery
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Andrea Haree Pantoja-Urban
2Integrated Program in Neuroscience, McGill University, Montréal, Quebec, H3A 2B4, Canada
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Michel Giroux
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Dominique Nouel
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Giovanni Hernandez
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Taylor Orsini
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Cecilia Flores
1Department of Psychiatry and Department of Neurology and Neurosurgery
3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0045-21.2021
PubMed 
33619036
Published By 
Society for Neuroscience
History 
  • Received February 1, 2021
  • Accepted February 3, 2021
  • Published online February 22, 2021.
Copyright & Usage 
Copyright © 2021 Vassilev et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Philip Vassilev1,3,*,
  2. Andrea Haree Pantoja-Urban2,*,
  3. Michel Giroux3,
  4. Dominique Nouel3,
  5. Giovanni Hernandez3,
  6. Taylor Orsini3 and
  7. Cecilia Flores1,3
  1. 1Department of Psychiatry and Department of Neurology and Neurosurgery
  2. 2Integrated Program in Neuroscience, McGill University, Montréal, Quebec, H3A 2B4, Canada
  3. 3Douglas Mental Health University Institute, Montreal, Quebec, H4H 1R3, Canada
  1. Correspondence should be addressed to Cecilia Flores at cecilia.flores{at}mcgill.ca.
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Author contributions

  1. Author contributions: P.V., A.H.P.-U., and C.F. designed research; P.V., A.H.P.-U., M.G., D.N., G.H., and T.O. performed research; P.V., A.H.P.-U., and M.G. analyzed data; P.V., A.H.P.-U., and C.F. wrote the paper.

  2. ↵* P.V. and A.H.P.-U. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by the National Institute on Drug Abuse CF Grant R01DA037911, the Canadian Institutes for Health Research CF Grant MOP-74709, and the Natural Sciences and Engineering Research Council of Canada CF Grant 2982226. A.H.P.-U. is supported by the National Council of Science and Technology/Consejo Nacional de Ciencia y Tecnología from México and Fonds de Recherche du Québec–Nature et Technologies-Merit Scholarship Program for foreign students (PBEEE).

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    MOP-74709
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    R01DA037911
  • Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (CANRIMT, NSERC)

    2982226
  • Consejo Nacional de Ciencia y Tecnología (CONACYT)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 22, 2021).

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Feb 2021277052
Mar 20213710114
Apr 202110216367
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Jun 20211623243
Jul 2021921218
Aug 20211021232
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Total 20218601674502
Jan 20221312735
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Apr 202227121
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May 20241210639
Jun 202469329
Jul 202499923
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Total 20241221438343
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Feb 20253212539
Mar 20251013323
Apr 20251211327
May 2025710418
Jun 20251412525
Jul 202584712
Total 202593801185
Total121364431674
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Unique Effects of Social Defeat Stress in Adolescent Male Mice on the Netrin-1/DCC Pathway, Prefrontal Cortex Dopamine and Cognition
Philip Vassilev, Andrea Haree Pantoja-Urban, Michel Giroux, Dominique Nouel, Giovanni Hernandez, Taylor Orsini, Cecilia Flores
eNeuro 22 February 2021, 8 (2) ENEURO.0045-21.2021; DOI: 10.1523/ENEURO.0045-21.2021

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Unique Effects of Social Defeat Stress in Adolescent Male Mice on the Netrin-1/DCC Pathway, Prefrontal Cortex Dopamine and Cognition
Philip Vassilev, Andrea Haree Pantoja-Urban, Michel Giroux, Dominique Nouel, Giovanni Hernandez, Taylor Orsini, Cecilia Flores
eNeuro 22 February 2021, 8 (2) ENEURO.0045-21.2021; DOI: 10.1523/ENEURO.0045-21.2021
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Keywords

  • adolescence
  • developmental biology
  • dopamine
  • guidance cues
  • prefrontal cortex
  • social defeat stress

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Disorders of the Nervous System

  • Reinforced odor representations in the anterior olfactory nucleus can serve as memory traces for conspecifics
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  • A novel subpopulation of prepositus hypoglossi nucleus neurons projecting to the cerebellar anterior vermis and hemisphere in rats.
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