Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Development

SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain

Monika Jain, Soumen Das, Paul P. Y. Lu, Garima Virmani, Sumitha Soman, Surya Chandra Rao Thumu, David H. Gutmann and Narendrakumar Ramanan
eNeuro 13 January 2021, 8 (1) ENEURO.0447-19.2020; https://doi.org/10.1523/ENEURO.0447-19.2020
Monika Jain
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soumen Das
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Soumen Das
Paul P. Y. Lu
2Jiangsu Hengrui Medicine, Cambridge, MA 02139
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Garima Virmani
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sumitha Soman
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Surya Chandra Rao Thumu
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David H. Gutmann
3Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Narendrakumar Ramanan
1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Narendrakumar Ramanan
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0447-19.2020
PubMed 
33441399
Published By 
Society for Neuroscience
History 
  • Received October 28, 2019
  • Revision received December 24, 2020
  • Accepted December 24, 2020
  • Published online January 13, 2021.
Copyright & Usage 
Copyright © 2021 Jain et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Monika Jain1,
  2. Soumen Das1,
  3. Paul P. Y. Lu2,
  4. Garima Virmani1,
  5. Sumitha Soman1,
  6. Surya Chandra Rao Thumu1,
  7. David H. Gutmann3 and
  8. Narendrakumar Ramanan1
  1. 1Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka 560012, India
  2. 2Jiangsu Hengrui Medicine, Cambridge, MA 02139
  3. 3Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110
  1. Correspondence should be addressed to Narendrakumar Ramanan at naren{at}iisc.ac.in.
View Full Text

Author contributions

  1. Author contributions: N.R. designed research; M.J., S.D., P.P.Y.L., G.V., S.S., S.C.R.T., and N.R. performed research; D.H.G. contributed unpublished reagents/analytic tools; M.J., S.D., P.P.Y.L., G.V., S.S., S.C.R.T., and N.R. analyzed data; M.J. and N.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Swarnajayanti Fellowship DST/SJF/LSA-01/2012-2013, the Department of Science and Technology, India (N.R.), the Department of Biotechnology (DBT) Grant BT/PR26216/GET/119/234/2017 (to N.R.), a Department of Biotechnology-Indian Institute of Science Partnership Program grant (N.R). M.J. and S.D. were supported by a senior research fellowship from the University Grants Commission, India. G.V. was supported by a senior research fellowship from the Council for Scientific and Industrial Research, India. S.C.R.T. was supported by the Department of Science and Technology, India Postdoctoral Fellowship PDF/2017/001385.

Funding

  • Department of Science and Technology, Ministry of Science and Technology (DST)

    DST/SJF/LSA-01/2012-2013; PDF/2017/001385
  • Department of Biotechnology, Ministry of Science and Technology (DBT)

    BT/PR26216/GET/119/234/2017
  • DBT-IISc Partnership Program

  • University Grants Commission (UGC)

  • Council for Scientific and Industrial Research (CSIR) [India]

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 13, 2021).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-11-09
to
E.g., 2025-11-09

Article usage: January 2021 to November 2025

AbstractFullPdf
Jan 202143260155
Feb 202130029994
Mar 20215026648
Apr 20213722041
May 20211122025
Jun 20211522245
Jul 2021212322
Aug 2021412936
Sep 2021413039
Oct 20211015150
Nov 2021312542
Dec 2021311650
Total 20218712061647
Jan 20221013042
Feb 202257630
Mar 202228023
Apr 202208631
May 2022212027
Jun 2022210932
Jul 2022310918
Aug 202227718
Sep 202225523
Oct 202227130
Nov 202236623
Dec 202226219
Total 2022351041316
Jan 202327519
Feb 202317016
Mar 2023011820
Apr 202308011
May 202307516
Jun 20230859
Jul 202359019
Aug 202368929
Sep 202338215
Oct 20234958
Nov 20234898
Dec 20231410326
Total 2023391051196
Jan 20240899
Feb 202428315
Mar 202418512
Apr 20241212524
May 20241511032
Jun 202439214
Jul 2024118523
Aug 202477816
Sep 202498529
Oct 202477010
Nov 20245837
Dec 202439012
Total 2024751075203
Jan 202579124
Feb 202579817
Mar 2025210617
Apr 202528316
May 202529515
Jun 20251110711
Jul 202589429
Aug 2025169738
Sep 2025714427
Oct 20251315315
Nov 20255267
Total 2025801094216
Total110063221578
Back to top

In this issue

eneuro: 8 (1)
eNeuro
Vol. 8, Issue 1
January/February 2021
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain
Monika Jain, Soumen Das, Paul P. Y. Lu, Garima Virmani, Sumitha Soman, Surya Chandra Rao Thumu, David H. Gutmann, Narendrakumar Ramanan
eNeuro 13 January 2021, 8 (1) ENEURO.0447-19.2020; DOI: 10.1523/ENEURO.0447-19.2020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain
Monika Jain, Soumen Das, Paul P. Y. Lu, Garima Virmani, Sumitha Soman, Surya Chandra Rao Thumu, David H. Gutmann, Narendrakumar Ramanan
eNeuro 13 January 2021, 8 (1) ENEURO.0447-19.2020; DOI: 10.1523/ENEURO.0447-19.2020
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • astrogliosis
  • gliosis
  • reactive astrocytes
  • serum response factor

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • A progressive ratio task with costly resets reveals adaptive effort-delay tradeoffs
  • What is the difference between an impulsive and a timed anticipatory movement ?
  • Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons
Show more Research Article: New Research

Development

  • Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity
  • Layer-Specific Glutamatergic Inputs and Parvalbumin Interneurons Modulate Early Life Stress-Induced Alterations in Prefrontal Glutamate Release during Fear Conditioning in Pre-adolescent Rats
  • Treatment of Mitochondrial Disturbances due to Early Life Adversity in Mice Results in Restoration of Complex I Activity and Normal Reward Behavior
Show more Development

Subjects

  • Development
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.