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Research ArticleResearch Article: Confirmation, Disorders of the Nervous System

Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration

Kun-Che Chang, Minjuan Bian, Xin Xia, Ankush Madaan, Catalina Sun, Qizhao Wang, Liang Li, Michael Nahmou, Takahiko Noro, Satoshi Yokota, Joana Galvao, Alexander Kreymerman, Bogdan Tanasa, Yang Hu and Jeffrey L. Goldberg
eNeuro 13 January 2021, 8 (1) ENEURO.0358-20.2020; https://doi.org/10.1523/ENEURO.0358-20.2020
Kun-Che Chang
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
2Department of Ophthalmology, Louis J. Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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  • ORCID record for Kun-Che Chang
Minjuan Bian
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Xin Xia
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Ankush Madaan
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Catalina Sun
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Qizhao Wang
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Liang Li
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Michael Nahmou
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Takahiko Noro
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
3Department of Ophthalmology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
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Satoshi Yokota
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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  • ORCID record for Satoshi Yokota
Joana Galvao
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Alexander Kreymerman
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Bogdan Tanasa
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Yang Hu
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Jeffrey L. Goldberg
1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0358-20.2020
PubMed 
33441400
Published By 
Society for Neuroscience
History 
  • Received August 16, 2020
  • Revision received December 21, 2020
  • Accepted December 22, 2020
  • Published online January 13, 2021.
Copyright & Usage 
Copyright © 2021 Chang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kun-Che Chang1,2,
  2. Minjuan Bian1,
  3. Xin Xia1,
  4. Ankush Madaan1,
  5. Catalina Sun1,
  6. Qizhao Wang1,
  7. Liang Li1,
  8. Michael Nahmou1,
  9. Takahiko Noro1,3,
  10. Satoshi Yokota1,
  11. Joana Galvao1,
  12. Alexander Kreymerman1,
  13. Bogdan Tanasa1,
  14. Yang Hu1 and
  15. Jeffrey L. Goldberg1
  1. 1Spencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304
  2. 2Department of Ophthalmology, Louis J. Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
  3. 3Department of Ophthalmology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
  1. Correspondence should be addressed to Kun-Che Chang at kunche{at}stanford.edu or Jeffrey L. Goldberg at jlgjournals{at}gmail.com.
View Full Text

Author contributions

  1. Author contributions: K.-C.C. designed research; K.-C.C., M.B., X.X., A.M., C.S., Q.W., L.L., M.N., T.N., S.Y., and J.G. performed research; Q.W., L.L., and Y.H. contributed unpublished reagents/analytic tools; K.-C.C., M.B., X.X., and B.T. analyzed data; K.-C.C., A.K., and J.L.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This study was supported by the Gilbert Family Foundation, the BrightFocus Foundation, National Eye Institute Grants P30-EY026877 and F32-EY029137, and the Research to Prevent Blindness, Inc.

Funding

  • HHS | NIH | National Eye Institute (NEI)

    F32-EY029137; P30-EY026877
  • BrightFocus Foundation (BrightFocus)

  • Research to Prevent Blindness (RPB)

  • Gilbert Family Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 13, 2021).

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Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration
Kun-Che Chang, Minjuan Bian, Xin Xia, Ankush Madaan, Catalina Sun, Qizhao Wang, Liang Li, Michael Nahmou, Takahiko Noro, Satoshi Yokota, Joana Galvao, Alexander Kreymerman, Bogdan Tanasa, Yang Hu, Jeffrey L. Goldberg
eNeuro 13 January 2021, 8 (1) ENEURO.0358-20.2020; DOI: 10.1523/ENEURO.0358-20.2020

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Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration
Kun-Che Chang, Minjuan Bian, Xin Xia, Ankush Madaan, Catalina Sun, Qizhao Wang, Liang Li, Michael Nahmou, Takahiko Noro, Satoshi Yokota, Joana Galvao, Alexander Kreymerman, Bogdan Tanasa, Yang Hu, Jeffrey L. Goldberg
eNeuro 13 January 2021, 8 (1) ENEURO.0358-20.2020; DOI: 10.1523/ENEURO.0358-20.2020
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Keywords

  • optic nerve regeneration
  • retinal ganglion cell
  • Sox11
  • SUMOylation

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