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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Lytic Cell Death in Specific Microglial Subsets Is Required for Preventing Atypical Behavior in Mice

Hsiu-Chun Chuang, Eva K. Nichols, Isabella Rauch, Wei-Cheng Chang, Patrick M. Lin, Rhea Misra, Maiko Kitaoka, Russell E. Vance and Kaoru Saijo
eNeuro 7 January 2021, 8 (1) ENEURO.0342-20.2020; https://doi.org/10.1523/ENEURO.0342-20.2020
Hsiu-Chun Chuang
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Eva K. Nichols
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Isabella Rauch
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
2Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720-3200
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Wei-Cheng Chang
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Patrick M. Lin
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Rhea Misra
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Maiko Kitaoka
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
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Russell E. Vance
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
2Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720-3200
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Kaoru Saijo
1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
3Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720-3200
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0342-20.2020
PubMed 
33414187
Published By 
Society for Neuroscience
History 
  • Received August 9, 2020
  • Revision received December 15, 2020
  • Accepted December 17, 2020
  • Published online January 7, 2021.
Copyright & Usage 
Copyright © 2021 Chuang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hsiu-Chun Chuang1,
  2. Eva K. Nichols1,
  3. Isabella Rauch1,2,
  4. Wei-Cheng Chang1,
  5. Patrick M. Lin1,
  6. Rhea Misra1,
  7. Maiko Kitaoka1,
  8. Russell E. Vance1,2 and
  9. Kaoru Saijo1,3
  1. 1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200
  2. 2Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720-3200
  3. 3Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720-3200
  1. Correspondence should be addressed to Kaoru Saijo at ksaijo{at}berkeley.edu.
  • I. Rauch’s present address: Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239.

View Full Text

Author contributions

  1. Author contributions: H.-C.C., E.K.N., and K.S. designed research; H.-C.C., E.K.N., W.-C.C., P.M.L., R.M., and M.K. performed research; I.R. and R.E.V. contributed unpublished reagents/analytic tools; H.-C.C., E.K.N., and K.S. analyzed data; K.S. wrote the paper.

  2. *H.-C.C. and E.K.N. contributed equally to this work.

  • I. Rauch’s present address: Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239.

Disclosures

  • The authors declare no competing financial interests.

  • E.K.N. was supported by the Chancellor’s Fellowship, Elizabeth Roboz Einstein Fellowship, and University of California dissertation year fellowship. I.R. was supported by the Austrian Science Fund (the Erwin Schrödinger Fellowship). M.K. was supported by the Department of Molecular and Cell Biology, Training Grant 4T32GM07232-40 and National Science Foundation, Graduate Research Fellowship Program. R.E.V. is an Howard Hughes Medical Institute Investigator and is supported by National Institutes of Health (NIH) Grants AI075039 and AI063302. K.S. is supported by the NIH Grant R01HD092093, a Searle Scholarship, a Hellman Fellowship, and a Pew Scholarship.

Funding

  • Kinship Foundation

  • Hellman Fellowship

  • Pew Charitable Trusts

  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)

    AI075039; AI063302
  • Howard Hughes Medical Institute (HHMI)

  • NSF GRFP

  • training grant

    4T32GM07232-40
  • UC Berkeley

    UC dissertation year fellowship
  • HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    R01HD092093

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 07, 2021).

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Total 2025521203242
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Total 20262408
Total82562331367
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Lytic Cell Death in Specific Microglial Subsets Is Required for Preventing Atypical Behavior in Mice
Hsiu-Chun Chuang, Eva K. Nichols, Isabella Rauch, Wei-Cheng Chang, Patrick M. Lin, Rhea Misra, Maiko Kitaoka, Russell E. Vance, Kaoru Saijo
eNeuro 7 January 2021, 8 (1) ENEURO.0342-20.2020; DOI: 10.1523/ENEURO.0342-20.2020

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Lytic Cell Death in Specific Microglial Subsets Is Required for Preventing Atypical Behavior in Mice
Hsiu-Chun Chuang, Eva K. Nichols, Isabella Rauch, Wei-Cheng Chang, Patrick M. Lin, Rhea Misra, Maiko Kitaoka, Russell E. Vance, Kaoru Saijo
eNeuro 7 January 2021, 8 (1) ENEURO.0342-20.2020; DOI: 10.1523/ENEURO.0342-20.2020
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Keywords

  • behavior
  • cell death
  • microglia

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