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Research ArticleResearch Article: New Research, Disorders of the Nervous System

α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide

E. Hill, R. Gowers, M. J. E. Richardson and M. J. Wall
eNeuro 23 November 2020, 8 (1) ENEURO.0330-20.2020; DOI: https://doi.org/10.1523/ENEURO.0330-20.2020
E. Hill
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdoms
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R. Gowers
2Warwick Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom
3Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin 10115, Germany
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M. J. E. Richardson
2Warwick Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom
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M. J. Wall
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdoms
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0330-20.2020
PubMed 
33229413
Published By 
Society for Neuroscience
History 
  • Received July 27, 2020
  • Revision received October 13, 2020
  • Accepted October 18, 2020
  • Published online November 23, 2020.
Copyright & Usage 
Copyright © 2021 Hill et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. E. Hill1,
  2. R. Gowers2,3,
  3. M. J. E. Richardson2 and
  4. M. J. Wall1
  1. 1School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdoms
  2. 2Warwick Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom
  3. 3Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin 10115, Germany
  1. Correspondence should be addressed to M. J. Wall at mark.wall{at}warwick.ac.uk.
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Author contributions

  1. Author contributions: E.H., M.J.E.R., and M.J.W. designed research; E.H. performed research; E.H., R.G., and M.J.E.R. analyzed data; E.H., R.G., M.J.E.R., and M.J.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Biotechnology and Biological Science Research Council-funded PhD Studentship (E.H.) an Engineering and Physical Sciences Research Council-funded PhD Studentship (R.G.).

Funding

  • BBSRC

  • Engineering and Physical Sciences Research Council (EPSRC)

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  • You are viewing the most recent version of this article.
  • previous version (November 23, 2020).

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Nov 20203370135
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Total 20208410433
Jan 2021161227122
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May 2021924225
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Jul 2021213321
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May 2022111824
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Apr 202318511
May 202308015
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Jul 202369415
Aug 202339924
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Total 2023401050167
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α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide
E. Hill, R. Gowers, M. J. E. Richardson, M. J. Wall
eNeuro 23 November 2020, 8 (1) ENEURO.0330-20.2020; DOI: 10.1523/ENEURO.0330-20.2020

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α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide
E. Hill, R. Gowers, M. J. E. Richardson, M. J. Wall
eNeuro 23 November 2020, 8 (1) ENEURO.0330-20.2020; DOI: 10.1523/ENEURO.0330-20.2020
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Keywords

  • α-synuclein
  • dopamine
  • electrophysiology
  • KATP
  • patch clamp
  • substantia nigra

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