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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Developmental PCB Exposure Disrupts Synaptic Transmission and Connectivity in the Rat Auditory Cortex, Independent of Its Effects on Peripheral Hearing Threshold

Christopher M. Lee, Renee N. Sadowski, Susan L. Schantz and Daniel A. Llano
eNeuro 22 January 2021, 8 (1) ENEURO.0321-20.2021; https://doi.org/10.1523/ENEURO.0321-20.2021
Christopher M. Lee
1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Renee N. Sadowski
1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Susan L. Schantz
1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801
3Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802
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Daniel A. Llano
1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0321-20.2021
PubMed 
33483323
Published By 
Society for Neuroscience
History 
  • Received July 17, 2020
  • Revision received January 1, 2021
  • Accepted January 6, 2021
  • Published online January 22, 2021.
Copyright & Usage 
Copyright © 2021 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christopher M. Lee1,
  2. Renee N. Sadowski1,
  3. Susan L. Schantz1,3 and
  4. Daniel A. Llano1,2
  1. 1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  2. 2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  3. 3Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802
  1. Correspondence should be addressed to Daniel A. Llano at d-llano{at}illinois.edu.
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Author contributions

  1. Author contributions: C.M.L., R.N.S., S.L.S., and D.A.L. designed research; C.M.L. and R.N.S. performed research; C.M.L. and R.N.S. analyzed data; C.M.L., R.N.S., S.L.S., and D.A.L. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Environmental Health Sciences Grants NIEHS-R01 ES015687 (to S.L.S.) and NIEHS-T32 ES007326 (to C.M.L.), a Beckman Institute Postdoctoral Fellowship (R.N.S.), and funding from the University of Illinois Research Board.

Funding

  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    ES015687; ES007326
  • Beckman Institute Postdoctoral Fellows Award

  • Research Board at University of Illinois

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 22, 2021).

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Jan 2021122035
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Total 2025981197206
Jan 20261612021
Feb 20264271
Total 20262014722
Total12415895903
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Developmental PCB Exposure Disrupts Synaptic Transmission and Connectivity in the Rat Auditory Cortex, Independent of Its Effects on Peripheral Hearing Threshold
Christopher M. Lee, Renee N. Sadowski, Susan L. Schantz, Daniel A. Llano
eNeuro 22 January 2021, 8 (1) ENEURO.0321-20.2021; DOI: 10.1523/ENEURO.0321-20.2021

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Developmental PCB Exposure Disrupts Synaptic Transmission and Connectivity in the Rat Auditory Cortex, Independent of Its Effects on Peripheral Hearing Threshold
Christopher M. Lee, Renee N. Sadowski, Susan L. Schantz, Daniel A. Llano
eNeuro 22 January 2021, 8 (1) ENEURO.0321-20.2021; DOI: 10.1523/ENEURO.0321-20.2021
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Keywords

  • auditory cortex
  • laser photostimulation
  • patch-clamp
  • PCB
  • toxin
  • uncaging

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