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Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods

Molecular Diversity of Glutamatergic and GABAergic Synapses from Multiplexed Fluorescence Imaging

Eric Danielson, Karen Perez de Arce, Beth Cimini, Eike-Christian Wamhoff, Shantanu Singh, Jeffrey R. Cottrell, Anne E. Carpenter and Mark Bathe
eNeuro 21 December 2020, 8 (1) ENEURO.0286-20.2020; DOI: https://doi.org/10.1523/ENEURO.0286-20.2020
Eric Danielson
1Department of Biological Engineering, MIT, Cambridge 02142, MA
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Karen Perez de Arce
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge 02142, MA
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Beth Cimini
3Imaging Platform, Broad Institute of MIT and Harvard, Cambridge 02142, MA
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Eike-Christian Wamhoff
1Department of Biological Engineering, MIT, Cambridge 02142, MA
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Shantanu Singh
3Imaging Platform, Broad Institute of MIT and Harvard, Cambridge 02142, MA
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Jeffrey R. Cottrell
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge 02142, MA
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Anne E. Carpenter
3Imaging Platform, Broad Institute of MIT and Harvard, Cambridge 02142, MA
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Mark Bathe
1Department of Biological Engineering, MIT, Cambridge 02142, MA
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0286-20.2020
PubMed 
33355295
Published By 
Society for Neuroscience
History 
  • Received June 29, 2020
  • Revision received November 25, 2020
  • Accepted December 7, 2020
  • Published online December 21, 2020.
Copyright & Usage 
Copyright © 2021 Danielson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Eric Danielson1,
  2. Karen Perez de Arce2,
  3. Beth Cimini3,
  4. Eike-Christian Wamhoff1,
  5. Shantanu Singh3,
  6. Jeffrey R. Cottrell2,
  7. Anne E. Carpenter3 and
  8. Mark Bathe1
  1. 1Department of Biological Engineering, MIT, Cambridge 02142, MA
  2. 2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge 02142, MA
  3. 3Imaging Platform, Broad Institute of MIT and Harvard, Cambridge 02142, MA
  1. Correspondence should be addressed to Anne E. Carpenter at anne{at}broadinstitute.org or Mark Bathe at mark.bathe{at}mit.edu.
View Full Text

Author contributions

  1. Author contributions: M.B., E.D., K.P.d.A., J.R.C., and A.E.C. designed research; E.D. and K.P.d.A. performed research; B.C. and E.-C.W. contributed unpublished reagents/analytic tools; E.D., K.P.d.A., B.C., and S.S. analyzed data; M.B., E.D., K.P.d.A., B.C., E.-C.W., S.S., J.R.C., and A.E.C. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grant R01-MH112694 (to M.B. and J.R.C.) and the National Science Foundation Physics of Living Systems Grant 1707999 (to M.B.). J.R.C. was also supported by funding from the Stanley Center for Psychiatric Research.

Funding

  • HHS | National Institutes of Health (NIH)

    R01-MH112694
  • National Science Foundation (NSF)

    1707999

Other Version

  • previous version (December 21, 2020).
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Molecular Diversity of Glutamatergic and GABAergic Synapses from Multiplexed Fluorescence Imaging
Eric Danielson, Karen Perez de Arce, Beth Cimini, Eike-Christian Wamhoff, Shantanu Singh, Jeffrey R. Cottrell, Anne E. Carpenter, Mark Bathe
eNeuro 21 December 2020, 8 (1) ENEURO.0286-20.2020; DOI: 10.1523/ENEURO.0286-20.2020

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Molecular Diversity of Glutamatergic and GABAergic Synapses from Multiplexed Fluorescence Imaging
Eric Danielson, Karen Perez de Arce, Beth Cimini, Eike-Christian Wamhoff, Shantanu Singh, Jeffrey R. Cottrell, Anne E. Carpenter, Mark Bathe
eNeuro 21 December 2020, 8 (1) ENEURO.0286-20.2020; DOI: 10.1523/ENEURO.0286-20.2020
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Keywords

  • machine learning
  • multiplexed imaging
  • synaptic plasticity
  • synaptic scaling

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