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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity

Jonna M. Leyrer-Jackson, Michael Holter, Paula F. Overby, Jason M. Newbern, Michael D. Scofield, M. Foster Olive and Cassandra D. Gipson
eNeuro 25 November 2020, 8 (1) ENEURO.0276-20.2020; https://doi.org/10.1523/ENEURO.0276-20.2020
Jonna M. Leyrer-Jackson
1Department of Psychology, Arizona State University, Tempe, AZ 85281
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Michael Holter
2Department of Neuroscience, School of Life Sciences, Arizona State University, Tempe, AZ 85281
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Paula F. Overby
1Department of Psychology, Arizona State University, Tempe, AZ 85281
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Jason M. Newbern
2Department of Neuroscience, School of Life Sciences, Arizona State University, Tempe, AZ 85281
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Michael D. Scofield
3Department of Anesthesiology, Medical University of South Carolina, Charleston, SC 29425
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M. Foster Olive
1Department of Psychology, Arizona State University, Tempe, AZ 85281
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Cassandra D. Gipson
4Department of Family and Community Medicine, University of Kentucky, Lexington, KY 40536
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0276-20.2020
PubMed 
33239269
Published By 
Society for Neuroscience
History 
  • Received June 24, 2020
  • Revision received November 4, 2020
  • Accepted November 16, 2020
  • Published online November 25, 2020.
Copyright & Usage 
Copyright © 2021 Leyrer-Jackson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jonna M. Leyrer-Jackson1,
  2. Michael Holter2,
  3. Paula F. Overby1,
  4. Jason M. Newbern2,
  5. Michael D. Scofield3,
  6. M. Foster Olive1 and
  7. Cassandra D. Gipson4
  1. 1Department of Psychology, Arizona State University, Tempe, AZ 85281
  2. 2Department of Neuroscience, School of Life Sciences, Arizona State University, Tempe, AZ 85281
  3. 3Department of Anesthesiology, Medical University of South Carolina, Charleston, SC 29425
  4. 4Department of Family and Community Medicine, University of Kentucky, Lexington, KY 40536
  1. Correspondence should be addressed to Cassandra D. Gipson at cdgips2{at}uky.edu.
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Author contributions

  1. Author contributions: J.M.L.-J., M.D.S., M.F.O., and C.D.G. designed research; J.M.L.-J., M.H., P.F.O., J.M.N., and C.D.G. performed research; M.D.S. and M.F.O. contributed unpublished reagents/analytic tools; J.M.L.-J., P.F.O., J.M.N., and C.D.G. analyzed data; J.M.L.-J. and C.D.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants DA036569, DA036569-S1, DA044479, DA046526, and DA045881 (to C.D.G.), F32AA027962-01 (to J.M.L.-J.), DA042172 (to M.F.O.), and NS097537 (to J.M.N.) and by the Arizona Alzheimer’s Consortium (C.D.G.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA044479; DA046526; DA045881; DA042172
  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    AA027962
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS097537

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 25, 2020).

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Article usage: November 2020 to February 2026

AbstractFullPdf
Nov 2020158065
Dec 20203320126
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Jan 202195028
Feb 20219215462
Mar 20213423852
Apr 20212520839
May 2021920444
Jun 2021920336
Jul 2021611033
Aug 2021810736
Sep 202149338
Oct 202159751
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Total 20212931619506
Jan 202219733
Feb 2022410618
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Apr 202216516
May 202279831
Jun 202269617
Jul 202236120
Aug 202235221
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Feb 20230656
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May 202317116
Jun 202328111
Jul 202388122
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Total 202330880180
Jan 202459120
Feb 2024108315
Mar 202448921
Apr 202469723
May 202408422
Jun 2024129013
Jul 202438524
Aug 2024107519
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Total 202469994201
Jan 202528616
Feb 202559511
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Apr 202587422
May 20253889
Jun 2025128413
Jul 20251910044
Aug 2025129724
Sep 20251014515
Oct 2025912021
Nov 20251415336
Dec 2025714634
Total 20251051288262
Jan 2026815517
Feb 20262182
Total 20261017319
Total103257901618
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Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity
Jonna M. Leyrer-Jackson, Michael Holter, Paula F. Overby, Jason M. Newbern, Michael D. Scofield, M. Foster Olive, Cassandra D. Gipson
eNeuro 25 November 2020, 8 (1) ENEURO.0276-20.2020; DOI: 10.1523/ENEURO.0276-20.2020

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Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity
Jonna M. Leyrer-Jackson, Michael Holter, Paula F. Overby, Jason M. Newbern, Michael D. Scofield, M. Foster Olive, Cassandra D. Gipson
eNeuro 25 November 2020, 8 (1) ENEURO.0276-20.2020; DOI: 10.1523/ENEURO.0276-20.2020
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Keywords

  • Accumbens
  • cholinergic
  • glutamate
  • nicotine
  • plasticity
  • relapse

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