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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes

Nadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli-Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen and Johanna Myllyharju
eNeuro 9 December 2020, 8 (1) ENEURO.0253-20.2020; https://doi.org/10.1523/ENEURO.0253-20.2020
Nadiya Byts
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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  • ORCID record for Nadiya Byts
Subodh Sharma
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Jenny Laurila
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Prodeep Paudel
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Ilkka Miinalainen
2Biocenter Oulu, University of Oulu, Oulu 90014, Finland
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Veli-Pekka Ronkainen
2Biocenter Oulu, University of Oulu, Oulu 90014, Finland
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Reetta Hinttala
2Biocenter Oulu, University of Oulu, Oulu 90014, Finland
3PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu 90014, Finland
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Kid Törnquist
4Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku 20500, Finland
5Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki 00290, Finland
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Peppi Koivunen
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Johanna Myllyharju
1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0253-20.2020
PubMed 
33298456
Published By 
Society for Neuroscience
History 
  • Received June 12, 2020
  • Revision received November 9, 2020
  • Accepted November 27, 2020
  • Published online December 9, 2020.
Copyright & Usage 
Copyright © 2021 Byts et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nadiya Byts1,
  2. Subodh Sharma1,
  3. Jenny Laurila1,
  4. Prodeep Paudel1,
  5. Ilkka Miinalainen2,
  6. Veli-Pekka Ronkainen2,
  7. Reetta Hinttala2,3,
  8. Kid Törnquist4,5,
  9. Peppi Koivunen1 and
  10. Johanna Myllyharju1
  1. 1Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
  2. 2Biocenter Oulu, University of Oulu, Oulu 90014, Finland
  3. 3PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu 90014, Finland
  4. 4Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku 20500, Finland
  5. 5Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki 00290, Finland
  1. Correspondence should be addressed to Johanna Myllyharju at johanna.myllyharju{at}oulu.fi.
View Full Text

Author contributions

  1. Author contributions: N.B., I.M., V.-P.R., R.H., K.T., P.K., and J.M. designed research; N.B., S.S., J.L., P.P., I.M., and V.-P.R. performed research; N.B., S.S., J.L., P.P., I.M., V.-P.R., R.H., K.T., P.K., and J.M. analyzed data; N.B. and J.M. wrote the paper.

Disclosures

  • J.M. owns equity in FibroGen Inc., which develops HIF-P4H inhibitors as potential therapeutics. This company supports research in the J.M. group. All other authors declare no competing financial interests.

  • This work was supported by Academy of Finland Project Grants 296498 (to J.M.) and 266719 and 308009 (to P.K.), the Academy of Finland Center of Excellence 2012-2017 Grant 251314 (to J.M.), the S. Jusélius Foundation (J.M., P.K.), the Jane and Aatos Erkko Foundation (J.M., P.K.), and FibroGen Inc. (J.M.).

Funding

  • Academy of Finland | Terveyden Tutkimuksen Toimikunta (Forskningsrådet för Hälsa)

    296498; 266719; 308009
  • Suomen Akatemia (Academy of Finland)

    251314
  • Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)

  • Jane ja Aatos Erkon Säätiö (J&AE)

  • FibroGen (FibroGen Inc.)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 09, 2020).

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Article usage: December 2020 to March 2026

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Dec 20203350124
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Total 20251041483259
Jan 20262228915
Feb 20261433116
Mar 202671396
Total 20264375937
Total131371021611
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Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes
Nadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli-Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen, Johanna Myllyharju
eNeuro 9 December 2020, 8 (1) ENEURO.0253-20.2020; DOI: 10.1523/ENEURO.0253-20.2020

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Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes
Nadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli-Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen, Johanna Myllyharju
eNeuro 9 December 2020, 8 (1) ENEURO.0253-20.2020; DOI: 10.1523/ENEURO.0253-20.2020
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Keywords

  • calcium signaling
  • hypoxia-inducible factor
  • prolyl 4-hydroxylase
  • vesicular exocytosis

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