Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes

Nadiya Byts; Subodh Sharma; Jenny Laurila; Prodeep Paudel; Ilkka Miinalainen; Veli-Pekka Ronkainen; Reetta Hinttala; Kid Törnquist; Peppi Koivunen; Johanna Myllyharju

doi:10.1523/ENEURO.0253-20.2020

Article Information

DOI

https://doi.org/10.1523/ENEURO.0253-20.2020

PubMed

33298456

Published By

Society for Neuroscience

History

Received June 12, 2020
Revision received November 9, 2020
Accepted November 27, 2020
Published online December 9, 2020.

Copyright © 2021 Byts et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

Nadiya Byts¹,
Subodh Sharma¹,
Jenny Laurila¹,
Prodeep Paudel¹,
Ilkka Miinalainen²,
Veli-Pekka Ronkainen²,
Reetta Hinttala²,³,
Kid Törnquist⁴,⁵,
Peppi Koivunen¹ and
Johanna Myllyharju¹

¹Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
²Biocenter Oulu, University of Oulu, Oulu 90014, Finland
³PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu 90014, Finland
⁴Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku 20500, Finland
⁵Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki 00290, Finland

Correspondence should be addressed to Johanna Myllyharju at johanna.myllyharju{at}oulu.fi.

View Full Text

Author contributions

Author contributions: N.B., I.M., V.-P.R., R.H., K.T., P.K., and J.M. designed research; N.B., S.S., J.L., P.P., I.M., and V.-P.R. performed research; N.B., S.S., J.L., P.P., I.M., V.-P.R., R.H., K.T., P.K., and J.M. analyzed data; N.B. and J.M. wrote the paper.

View Abstract

Disclosures

J.M. owns equity in FibroGen Inc., which develops HIF-P4H inhibitors as potential therapeutics. This company supports research in the J.M. group. All other authors declare no competing financial interests.
This work was supported by Academy of Finland Project Grants 296498 (to J.M.) and 266719 and 308009 (to P.K.), the Academy of Finland Center of Excellence 2012-2017 Grant 251314 (to J.M.), the S. Jusélius Foundation (J.M., P.K.), the Jane and Aatos Erkko Foundation (J.M., P.K.), and FibroGen Inc. (J.M.).

Funding

Academy of Finland | Terveyden Tutkimuksen Toimikunta (Forskningsrådet för Hälsa)
296498; 266719; 308009
Suomen Akatemia (Academy of Finland)
251314
Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)
Jane ja Aatos Erkon Säätiö (J&AE)
FibroGen (FibroGen Inc.)