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Research ArticleResearch Article: New Research, Sensory and Motor Systems

The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia

Anisha Rastogi, Francis R. Willett, Jessica Abreu, Douglas C. Crowder, Brian A. Murphy, William D. Memberg, Carlos E. Vargas-Irwin, Jonathan P. Miller, Jennifer Sweet, Benjamin L. Walter, Paymon G. Rezaii, Sergey D. Stavisky, Leigh R. Hochberg, Krishna V. Shenoy, Jaimie M. Henderson, Robert F. Kirsch and A. Bolu Ajiboye
eNeuro 25 January 2021, 8 (1) ENEURO.0231-20.2020; DOI: https://doi.org/10.1523/ENEURO.0231-20.2020
Anisha Rastogi
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
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Francis R. Willett
2Department of Neurosurgery, Stanford University, Stanford, CA 94035
3Department of Electrical Engineering, Stanford University, Stanford, CA 94035
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Jessica Abreu
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
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Douglas C. Crowder
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
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Brian A. Murphy
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
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William D. Memberg
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
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Carlos E. Vargas-Irwin
5Department of Neuroscience, Brown University, Providence, RI 02912
6Robert J. and Nancy D. Carney Institute for Brain Sciences, Brown University, Providence, RI 02912
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Jonathan P. Miller
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
8Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
9Department of Neurological Surgery, Case Western Reserve School of Medicine School of Medicine, Cleveland, OH 44106
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Jennifer Sweet
8Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
9Department of Neurological Surgery, Case Western Reserve School of Medicine School of Medicine, Cleveland, OH 44106
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Benjamin L. Walter
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
10Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
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Paymon G. Rezaii
2Department of Neurosurgery, Stanford University, Stanford, CA 94035
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Sergey D. Stavisky
2Department of Neurosurgery, Stanford University, Stanford, CA 94035
3Department of Electrical Engineering, Stanford University, Stanford, CA 94035
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Leigh R. Hochberg
6Robert J. and Nancy D. Carney Institute for Brain Sciences, Brown University, Providence, RI 02912
7VA RR&D Center for Neurorestoration and Neurotechnology, Providence, RI 02912
11School of Engineering, Brown University, Providence, RI 02912
12Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114
13Department of Neurology, Harvard Medical School, Boston, MA 02114
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Krishna V. Shenoy
3Department of Electrical Engineering, Stanford University, Stanford, CA 94035
14Department of Bioengineering, Stanford University, Stanford, CA 94035
15Department of Neurobiology, Stanford University, Stanford, CA 94035
16Howard Hughes Medical Institute at Stanford University, Stanford, CA 94035
17Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94035
18Bio-X Program, Stanford University, Stanford, CA 94035
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Jaimie M. Henderson
2Department of Neurosurgery, Stanford University, Stanford, CA 94035
17Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94035
18Bio-X Program, Stanford University, Stanford, CA 94035
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Robert F. Kirsch
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
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A. Bolu Ajiboye
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0231-20.2020
PubMed 
33495242
Published By 
Society for Neuroscience
History 
  • Received May 30, 2020
  • Revision received October 17, 2020
  • Accepted October 20, 2020
  • Published online January 25, 2021.
Copyright & Usage 
Copyright © 2021 Rastogi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Anisha Rastogi1,
  2. Francis R. Willett2,3,
  3. Jessica Abreu1,4,
  4. Douglas C. Crowder1,4,
  5. Brian A. Murphy1,4,
  6. William D. Memberg1,
  7. Carlos E. Vargas-Irwin5,6,
  8. Jonathan P. Miller4,8,9,
  9. Jennifer Sweet8,9,
  10. Benjamin L. Walter4,10,
  11. Paymon G. Rezaii2,
  12. Sergey D. Stavisky2,3,
  13. Leigh R. Hochberg6,7,11,12,13,
  14. Krishna V. Shenoy3,14,15,16,17,18,
  15. Jaimie M. Henderson2,17,18,
  16. Robert F. Kirsch1,4 and
  17. A. Bolu Ajiboye1,4
  1. 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106
  2. 2Department of Neurosurgery, Stanford University, Stanford, CA 94035
  3. 3Department of Electrical Engineering, Stanford University, Stanford, CA 94035
  4. 4Louis Stokes Cleveland Department of VA Medical Center, Cleveland, OH 44106
  5. 5Department of Neuroscience, Brown University, Providence, RI 02912
  6. 6Robert J. and Nancy D. Carney Institute for Brain Sciences, Brown University, Providence, RI 02912
  7. 7VA RR&D Center for Neurorestoration and Neurotechnology, Providence, RI 02912
  8. 8Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
  9. 9Department of Neurological Surgery, Case Western Reserve School of Medicine School of Medicine, Cleveland, OH 44106
  10. 10Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
  11. 11School of Engineering, Brown University, Providence, RI 02912
  12. 12Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114
  13. 13Department of Neurology, Harvard Medical School, Boston, MA 02114
  14. 14Department of Bioengineering, Stanford University, Stanford, CA 94035
  15. 15Department of Neurobiology, Stanford University, Stanford, CA 94035
  16. 16Howard Hughes Medical Institute at Stanford University, Stanford, CA 94035
  17. 17Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94035
  18. 18Bio-X Program, Stanford University, Stanford, CA 94035
  1. Correspondence should be addressed to A. Bolu Ajiboye at bolu.ajiboye{at}case.edu.
View Full Text

Author contributions

  1. Author contributions: A.R., F.R.W., B.A.M., C.E.V.-I., L.R.H., K.V.S., J.M.H., R.F.K., and A.B.A. designed research; A.R., B.A.M., W.D.M., J.P.M., J.S., B.L.W., P.G.R., and S.D.S. performed research; A.R., F.R.W., J.A., and D.C.C. analyzed data; A.R., F.R.W., S.D.S., and A.B.A. wrote the paper.

Disclosures

  • The MGH Translational Research Center has a clinical research support agreement with Neuralink, Paradromics, and Synchron, for which L.M.H. provides consultative input. K.V.S. is a consultant to Neuralink Corp. and on the Scientific Advisory Boards of CTRL-Labs, Inc., MIND-X Inc., Inscopix Inc., and Heal, Inc. J.M.H. is a consultant for Neuralink, Proteus Biomedical, and Boston Scientific and serves on the Medical Advisory Board of Enspire DBS. This work was independent of and not supported by these commercial entities. All other authors declare no competing financial interests.

  • This work was supported by National Institute of Child Health and Human Development-National Center for Medical Rehabilitation Research Grants R01HD077220 (to B.L.W. and R.F.K.) and F30HD090890 (to A.R.); National Institute on Deafness and Other Communication Disorders Grants R01DC009899 (to L.R.H.) and R01DC014034 (to K.V.S. and J.M.H.); National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke Grants UH2NS095548 and 5U01NS098968-02 (to L.R.H.); NIH Institutional Training Grants 5 TL1 TR 441-7 and 5T32EB004314-15 (to A.R.); Department of Veteran Affairs Office of Research and Development Rehabilitation R&D Service Grants N2864C, N9228C, A2295R, B6453R, and A6779I (to L.R.H.) and A2654R (to A.B.A.); the Howard Hughes Medical Institute (F.R.W. and K.V.S.); MGH-Deane Institute (L.R.H.); the Executive Committee on Research of Massachusetts General Hospital (L.R.H.); the Wu Tsai Neurosciences Institute (F.R.W., S.D.S., K.V.S., J.M.H.); the ALS Association Milton Safenowitz Postdoctoral Fellowship (S.D.S.); the A.P. Giannini Foundation Postdoctoral Fellowship (S.D.S.); the Wu Tsai Neurosciences Institute Interdisciplinary Scholars Fellowship; the Larry and Pamela Garlick Foundation; the Simons Foundation Collaboration on the Global Brain Grant 543045; and Samuel and Betsy Reeves.

  • B. L. Walter’s present address: Department of Neurology and Neurosurgery, Cleveland Clinic, Cleveland, OH 44106.

Funding

  • NIH Institutional Training Grants

    5 TL1 TR 441-7; 5T32EB004314-15
  • HHS | NIH | NICHD | National Center for Medical Rehabilitation Research (NCMRR)

    NCMRR F30HD090890; R01HD077220; R01HD077220; R01HD077220
  • The Wu Tsai Neurosciences Institute

  • Howard Hughes Medical Institute (HHMI)

  • The ALS Association Milton Safenowitz Postdoctoral Fellowship

  • The A.P. Giannini Postdoctoral Fellowship

  • MGH-Deane Institute

  • The Executive Committee on Research (ECOR) of Massachusetts General Hospital

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    R01DC009899; R01DC014034; R01DC014034
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    UH2NS095548; 5U01NS098968-02
  • Department of Veteran Affairs Office of Research and Development Rehabilitation R&D Service

    N2864C; N9288C; A2295R; B6453R; A6779I; A2654R
  • The Wu Tsai Neuroscience Institute

Other Version

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The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia
Anisha Rastogi, Francis R. Willett, Jessica Abreu, Douglas C. Crowder, Brian A. Murphy, William D. Memberg, Carlos E. Vargas-Irwin, Jonathan P. Miller, Jennifer Sweet, Benjamin L. Walter, Paymon G. Rezaii, Sergey D. Stavisky, Leigh R. Hochberg, Krishna V. Shenoy, Jaimie M. Henderson, Robert F. Kirsch, A. Bolu Ajiboye
eNeuro 25 January 2021, 8 (1) ENEURO.0231-20.2020; DOI: 10.1523/ENEURO.0231-20.2020

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The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia
Anisha Rastogi, Francis R. Willett, Jessica Abreu, Douglas C. Crowder, Brian A. Murphy, William D. Memberg, Carlos E. Vargas-Irwin, Jonathan P. Miller, Jennifer Sweet, Benjamin L. Walter, Paymon G. Rezaii, Sergey D. Stavisky, Leigh R. Hochberg, Krishna V. Shenoy, Jaimie M. Henderson, Robert F. Kirsch, A. Bolu Ajiboye
eNeuro 25 January 2021, 8 (1) ENEURO.0231-20.2020; DOI: 10.1523/ENEURO.0231-20.2020
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Keywords

  • brain-computer interface
  • force
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  • kinetic
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