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Research ArticleResearch Article: New Research, Integrative Systems

A Focal Inactivation and Computational Study of Ventrolateral Periaqueductal Gray and Deep Mesencephalic Reticular Nucleus Involvement in Sleep State Switching and Bistability

Kevin P. Grace and Richard L. Horner
eNeuro 14 October 2020, 7 (6) ENEURO.0451-19.2020; https://doi.org/10.1523/ENEURO.0451-19.2020
Kevin P. Grace
1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
4Department of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02215
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Richard L. Horner
2Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0451-19.2020
PubMed 
33055199
Published By 
Society for Neuroscience
History 
  • Received October 29, 2019
  • Revision received October 2, 2020
  • Accepted October 6, 2020
  • Published online October 14, 2020.
Copyright & Usage 
Copyright © 2020 Grace and Horner This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kevin P. Grace1,4 and
  2. Richard L. Horner2,3
  1. 1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
  2. 2Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
  3. 3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
  4. 4Department of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine, Harvard Medical School, Boston, MA 02215
  1. Correspondence should be addressed to Kevin P. Grace at kpgrace{at}bidmc.harvard.edu.
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Author contributions

  1. Author contributions: K.P.G. designed research; K.P.G. performed research; K.P.G. and R.L.H. contributed unpublished reagents/analytic tools; K.P.G. analyzed data; K.P.G. and R.L.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research (CIHR) Grant MT-15563 (to R.L.H); the National Sanitarium Association Innovative Research Program Fund Number 00144051 (to R.L.H); the Tier 1 Canada Research Chair in Sleep and Respiratory Neurobiology Fund Number 950-229813 (to R.L.H.); a CIHR Doctoral Award–Fredrick Banting and Charles Best Canada Graduate Scholarship (CGS-D; to K.P.G.), the CIHR Team Research and Training Grant in Sleep and Biological Rhythms Grant TGS-109218 (to R. L. H.), and a Queen Elizabeth II/Grace Lumsden/Margaret Nicholds Scholarship in Science and Technology (QEII-GSST).

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    MT-15563
  • National Sanitarium Association Innovative Research Program

    00144051
  • Gouvernement du Canada | Canadian Institutes of Health Research CRC

    950-229813
  • Gouvernement du Canada | Canadian Institutes of Health Research Doctoral award

    CGS-D
  • Gouvernement du Canada | Canadian Institutes of Health Research Team Grant in Sleep and Biological Rhythms

    TGS-109218
  • Queen Elizabeth II/Grace Lumsden/Margaret Nicholds Scholarship in Science and Technology

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 14, 2020).

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Article usage: October 2020 to March 2026

AbstractFullPdf
Oct 2020180049
Nov 2020119240
Dec 20201378156
Total 202043683145
Jan 20213316731
Feb 20212813021
Mar 20211719835
Apr 20211418724
May 2021610922
Jun 2021811530
Jul 202127914
Aug 202157615
Sep 2021311527
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Dec 202128115
Total 20211271430286
Jan 202229528
Feb 202224415
Mar 202234918
Apr 202215015
May 202208123
Jun 202237812
Jul 202204119
Aug 202234811
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Total 202228722198
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Apr 202337612
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Jun 202326413
Jul 202358828
Aug 202386932
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Total 202337862180
Jan 20247867
Feb 202477226
Mar 202448813
Apr 2024910328
May 202458214
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Jul 202468122
Aug 202478015
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Total 202476969179
Jan 202548929
Feb 2025011619
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Apr 202557523
May 202529415
Jun 202539329
Jul 2025710730
Aug 202558947
Sep 20251724437
Oct 2025119622
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Dec 2025816549
Total 2025791360326
Jan 20261917424
Feb 20261044619
Mar 202627718
Total 20263169761
Total81461231375
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A Focal Inactivation and Computational Study of Ventrolateral Periaqueductal Gray and Deep Mesencephalic Reticular Nucleus Involvement in Sleep State Switching and Bistability
Kevin P. Grace, Richard L. Horner
eNeuro 14 October 2020, 7 (6) ENEURO.0451-19.2020; DOI: 10.1523/ENEURO.0451-19.2020

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A Focal Inactivation and Computational Study of Ventrolateral Periaqueductal Gray and Deep Mesencephalic Reticular Nucleus Involvement in Sleep State Switching and Bistability
Kevin P. Grace, Richard L. Horner
eNeuro 14 October 2020, 7 (6) ENEURO.0451-19.2020; DOI: 10.1523/ENEURO.0451-19.2020
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Keywords

  • EEG
  • microdialysis
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  • REM sleep
  • state dynamics

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