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Review, Disorders of the Nervous System

Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease

Nicholas J. Izzo, Martí Colom-Cadena, Aladdin A. Riad, Jinbin Xu, Meharvan Singh, Carmen Abate, Michael A. Cahill, Tara L. Spires-Jones, Wayne D. Bowen, Robert H. Mach and Susan M. Catalano
eNeuro 7 October 2020, 7 (6) ENEURO.0317-20.2020; DOI: https://doi.org/10.1523/ENEURO.0317-20.2020
Nicholas J. Izzo
1Cognition Therapeutics Inc, Pittsburgh, PA, 15203
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Martí Colom-Cadena
2UK Dementia Research Institute and The University of Edinburgh, Edinburgh, United Kingdom, EH8 9JZ
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Aladdin A. Riad
3The University of Pennsylvania, Department of Radiology, Philadelphia, PA, 19104
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Jinbin Xu
4Washington University School of Medicine, Department of Radiology, St. Louis, MO, 63110
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Meharvan Singh
5Loyola University Chicago Stritch School of Medicine, Department of Cellular and Molecular Physiology, Maywood, IL, 60153
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Carmen Abate
6Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, I-70125 Bari, Italy
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Michael A. Cahill
7School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, 2650 Australia
8Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, 2601 Australia
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Tara L. Spires-Jones
2UK Dementia Research Institute and The University of Edinburgh, Edinburgh, United Kingdom, EH8 9JZ
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Wayne D. Bowen
9Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912
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Robert H. Mach
3The University of Pennsylvania, Department of Radiology, Philadelphia, PA, 19104
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Susan M. Catalano
1Cognition Therapeutics Inc, Pittsburgh, PA, 15203
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0317-20.2020
PubMed 
33028631
Published By 
Society for Neuroscience
History 
  • Received July 31, 2020
  • Revision received September 10, 2020
  • Accepted September 12, 2020
  • Published online October 7, 2020.
Copyright & Usage 
Copyright © 2020 Izzo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nicholas J. Izzo1,
  2. Martí Colom-Cadena2,
  3. Aladdin A. Riad3,
  4. Jinbin Xu4,
  5. Meharvan Singh5,
  6. Carmen Abate6,
  7. Michael A. Cahill7,8,
  8. Tara L. Spires-Jones2,
  9. Wayne D. Bowen9,
  10. Robert H. Mach3 and
  11. Susan M. Catalano1
  1. 1Cognition Therapeutics Inc, Pittsburgh, PA, 15203
  2. 2UK Dementia Research Institute and The University of Edinburgh, Edinburgh, United Kingdom, EH8 9JZ
  3. 3The University of Pennsylvania, Department of Radiology, Philadelphia, PA, 19104
  4. 4Washington University School of Medicine, Department of Radiology, St. Louis, MO, 63110
  5. 5Loyola University Chicago Stritch School of Medicine, Department of Cellular and Molecular Physiology, Maywood, IL, 60153
  6. 6Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, I-70125 Bari, Italy
  7. 7School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, 2650 Australia
  8. 8Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, 2601 Australia
  9. 9Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912
  1. Correspondence should be addressed to Susan M. Catalano at scatalano{at}cogrx.com.
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Author contributions

  1. Author contributions: N.J.I., M.C.-C., A.A.R., J.X., M.S., C.A., M.A.C., T.L.S.-J., W.D.B., R.H.M., and S.M.C. designed research; N.J.I., M.C.-C., A.A.R., J.X., M.S., C.A., M.A.C., T.L.S.-J., W.D.B., R.H.M., and S.M.C. performed research; N.J.I., M.C.-C., A.A.R., J.X., M.S., C.A., M.A.C., T.L.S.-J., W.D.B., R.H.M., and S.M.C. analyzed data; N.J.I., M.C.-C., A.A.R., J.X., M.S., C.A., M.A.C., T.L.S.-J., W.D.B., R.H.M., and S.M.C. wrote the paper.

Disclosures

  • The authors declare no competing financial interests. N.J.I. and S.M.C. are employees of Cognition Therapeutics, Inc.

  • This work was supported by the Alzheimer's Society, European Research Commission Grant 681181 and the UK Dementia Research Institute (to T.L.S.-J.), National Institutes of Health (NIH) NIA National Institute on Aging Grants AG037337, AG055247, AG051593, and AG054176 (to S.M.C.), the NIH Grant AG027956 (to M.S.), Upjohn Professorship in Pharmacology, Brown University (W.D.B.), and the NIH National Institute of Neurological Disorders and Stroke Grant 1R01NS092865 (to J.X.). M.A.C. was primarily supported by Charles Sturt University internal funds, and collaborators.

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Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease
Nicholas J. Izzo, Martí Colom-Cadena, Aladdin A. Riad, Jinbin Xu, Meharvan Singh, Carmen Abate, Michael A. Cahill, Tara L. Spires-Jones, Wayne D. Bowen, Robert H. Mach, Susan M. Catalano
eNeuro 7 October 2020, 7 (6) ENEURO.0317-20.2020; DOI: 10.1523/ENEURO.0317-20.2020

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Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease
Nicholas J. Izzo, Martí Colom-Cadena, Aladdin A. Riad, Jinbin Xu, Meharvan Singh, Carmen Abate, Michael A. Cahill, Tara L. Spires-Jones, Wayne D. Bowen, Robert H. Mach, Susan M. Catalano
eNeuro 7 October 2020, 7 (6) ENEURO.0317-20.2020; DOI: 10.1523/ENEURO.0317-20.2020
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  • Article
    • Abstract
    • Introduction
    • Metabolic Effects of S2R Ligands
    • Expression and Localization of S2R in the Brain
    • The S2R Complex and Aβ
    • The Role of the S2R Complex Protein PGRMC1 in Health and Pathology
    • Development of S2R Ligands
    • Conclusions and Future Directions
    • Footnotes
    • References
    • Synthesis
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Keywords

  • amyloid β
  • neurodegeneration
  • PGRMC1
  • SfN symposium
  • σ-2 receptor
  • TMEM97

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