Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses

Swarna Pandian; Jian-Ping Zhao; Yasunobu Murata; Fernando J. Bustos; Cansu Tunca; Ramiro D. Almeida; Martha Constantine-Paton

doi:10.1523/ENEURO.0284-20.2020

Article Information

DOI

https://doi.org/10.1523/ENEURO.0284-20.2020

PubMed

33229412

Published By

Society for Neuroscience

History

Received June 27, 2020
Revision received October 2, 2020
Accepted October 7, 2020
Published online November 23, 2020.

Copyright © 2020 Pandian et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

Swarna Pandian¹,³,⁴,
Jian-Ping Zhao¹,
Yasunobu Murata¹,
Fernando J. Bustos¹,²,
Cansu Tunca¹,
Ramiro D. Almeida³ and
Martha Constantine-Paton¹

¹Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139
²Institute of Biomedical Sciences, Faculty of Medicine and Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile 8370071
³Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal
⁴Instituto Superior Técnico Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal

Correspondence should be addressed to Fernando J. Bustos at fernando.bustos{at}unab.cl.

View Full Text

Author contributions

Author contributions: S.P., R.D.A., and M.C.-P. designed research; S.P., J.-P.Z., Y.M., and C.T. performed research; S.P., Y.M., F.J.B., and M.C.-P. analyzed data; S.P., F.J.B., and M.C.-P. wrote the paper.

View Abstract

Disclosures

The authors declare no competing financial interests.
This work was supported by National Institutes of Health Grants R01-EY014074 and R01-EY014420 (to M.C.P.). S.P. was supported by the MIT-Portugal Program, the Portuguese Foundation for Science and Technology Grant SFRH/BD/33726/2009 as a graduate student, and by the McGovern Institute for Brain Research as a postdoctoral fellow. F.J.B. was a Simons Center for the Social Brain Postdoctoral Fellow at MIT and a Pew Latin American Postdoctoral Fellow and is funded by the FONDECYT (Fondo Nacional de Desarrollo Científico y Tecnológico) 11180540. ANID (Agencia Nacional de Investigación y Desarrollo de Chile) PAI 77180077.