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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia

Sejal Patel, Derek Howard, Alana Man, Deborah Schwartz, Joelle Jee, Daniel Felsky, Zdenka Pausova, Tomas Paus and Leon French
eNeuro 24 November 2020, 7 (6) ENEURO.0255-20.2020; DOI: https://doi.org/10.1523/ENEURO.0255-20.2020
Sejal Patel
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
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Derek Howard
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
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Alana Man
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
2Victoria College, University of Toronto, Toronto, Ontario M5S 1K7, Canada
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Deborah Schwartz
3Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Ontario M6A 2E1, Canada
4Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
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Joelle Jee
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
5Faculty of Arts and Science, University of Toronto, Toronto, Ontario M5S 3G3, Canada
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Daniel Felsky
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
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Zdenka Pausova
6The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
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Tomas Paus
4Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
7Department of Psychiatry, University of Toronto, Ontario M5S 3G3, Toronto
8Institute for Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Leon French
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
7Department of Psychiatry, University of Toronto, Ontario M5S 3G3, Toronto
8Institute for Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
9Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1L8, Canada
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eneuro: 7 (6)
eNeuro
Vol. 7, Issue 6
November/December 2020
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Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia
Sejal Patel, Derek Howard, Alana Man, Deborah Schwartz, Joelle Jee, Daniel Felsky, Zdenka Pausova, Tomas Paus, Leon French
eNeuro 24 November 2020, 7 (6) ENEURO.0255-20.2020; DOI: 10.1523/ENEURO.0255-20.2020

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Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia
Sejal Patel, Derek Howard, Alana Man, Deborah Schwartz, Joelle Jee, Daniel Felsky, Zdenka Pausova, Tomas Paus, Leon French
eNeuro 24 November 2020, 7 (6) ENEURO.0255-20.2020; DOI: 10.1523/ENEURO.0255-20.2020
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Keywords

  • microglia
  • neurodegeneration
  • neuroinflammation
  • transcriptomics

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