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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in Drosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System

Shin-Hann Lee, Sarah M. Gomes, Judy Ghalayini, Konstantin G. Iliadi and Gabrielle L. Boulianne
eNeuro 15 October 2020, 7 (6) ENEURO.0235-20.2020; DOI: https://doi.org/10.1523/ENEURO.0235-20.2020
Shin-Hann Lee
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
2Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, CA
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Sarah M. Gomes
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
3Institute of Medical Science, University of Toronto, M5S 1A1, Toronto, ON, CA
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Judy Ghalayini
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
2Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, CA
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Konstantin G. Iliadi
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
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Gabrielle L. Boulianne
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
2Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, CA
3Institute of Medical Science, University of Toronto, M5S 1A1, Toronto, ON, CA
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0235-20.2020
PubMed 
33060184
Published By 
Society for Neuroscience
History 
  • Received June 5, 2020
  • Revision received September 29, 2020
  • Accepted October 1, 2020
  • Published online October 15, 2020.
Copyright & Usage 
Copyright © 2020 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Shin-Hann Lee1,2,*,
  2. Sarah M. Gomes1,3,*,
  3. Judy Ghalayini1,2,
  4. Konstantin G. Iliadi1 and
  5. Gabrielle L. Boulianne1,2,3
  1. 1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, M5G 0A4, Toronto, ON, CA
  2. 2Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, CA
  3. 3Institute of Medical Science, University of Toronto, M5S 1A1, Toronto, ON, CA
  1. Correspondence should be addressed to Gabrielle L. Boulianne at gboul{at}sickkids.ca.
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Author contributions

  1. Author contributions: S.-H.L., S.M.G., J.G., K.G.I., and G.L.B. designed research; S.-H.L., S.M.G., J.G., and K.G.I. performed research; S.-H.L., S.M.G., J.G., and K.G.I. contributed unpublished reagents/analytic tools; S.-H.L., S.M.G., J.G., K.G.I., and G.L.B. analyzed data; S.-H.L., S.M.G., J.G., K.G.I., and G.L.B. wrote the paper.

  2. ↵* S.-H.L. and S.M.G. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research Grant PJT153063, a Tier I Canada Research Chair in Molecular and Developmental Neurobiology (G.L.B.), a Hospital for Sick Children Restracomp Award (S.-H.L., S.M.G.), and a QE-II Graduate Scholarship in Science and Technology (S.-H.L.).

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    PJT153063

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Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in Drosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System
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Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in Drosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System
Shin-Hann Lee, Sarah M. Gomes, Judy Ghalayini, Konstantin G. Iliadi, Gabrielle L. Boulianne
eNeuro 15 October 2020, 7 (6) ENEURO.0235-20.2020; DOI: 10.1523/ENEURO.0235-20.2020

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Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in Drosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System
Shin-Hann Lee, Sarah M. Gomes, Judy Ghalayini, Konstantin G. Iliadi, Gabrielle L. Boulianne
eNeuro 15 October 2020, 7 (6) ENEURO.0235-20.2020; DOI: 10.1523/ENEURO.0235-20.2020
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Keywords

  • Alzheimer’s disease
  • amyloid
  • Drosophila
  • memory
  • presenilin
  • renin angiotensin system

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