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Research ArticleResearch Article: New Research, Cognition and Behavior

Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior

Krissy A. Lyon, Benjamin D. Rood, Lorna Wu, Rebecca A. Senft, Lisa V. Goodrich and Susan M. Dymecki
eNeuro 19 November 2020, 7 (6) ENEURO.0202-20.2020; DOI: https://doi.org/10.1523/ENEURO.0202-20.2020
Krissy A. Lyon
1Department of Genetics, Harvard Medical School, Boston, MA 02115
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Benjamin D. Rood
1Department of Genetics, Harvard Medical School, Boston, MA 02115
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Lorna Wu
2Department of Neurobiology, Harvard Medical School, Boston, MA 02115
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Rebecca A. Senft
1Department of Genetics, Harvard Medical School, Boston, MA 02115
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Lisa V. Goodrich
2Department of Neurobiology, Harvard Medical School, Boston, MA 02115
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Susan M. Dymecki
1Department of Genetics, Harvard Medical School, Boston, MA 02115
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0202-20.2020
PubMed 
33214315
Published By 
Society for Neuroscience
History 
  • Received May 19, 2020
  • Revision received October 19, 2020
  • Accepted November 9, 2020
  • Published online November 19, 2020.
Copyright & Usage 
Copyright © 2020 Lyon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Krissy A. Lyon1,
  2. Benjamin D. Rood1,
  3. Lorna Wu2,
  4. Rebecca A. Senft1,
  5. Lisa V. Goodrich2 and
  6. Susan M. Dymecki1
  1. 1Department of Genetics, Harvard Medical School, Boston, MA 02115
  2. 2Department of Neurobiology, Harvard Medical School, Boston, MA 02115
  1. Correspondence should be addressed to Susan M. Dymecki at dymecki{at}genetics.med.harvard.edu.
  • B. D. Rood’s present address: Department of Cell Biology and Neuroscience, Rowan University, Stratford, NJ 08084.

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Author contributions

  1. Author contributions: K.A.L. and S.M.D. designed research; K.A.L., B.D.R., and L.W. performed research; R.A.S. and L.V.G. contributed unpublished reagents/analytic tools; K.A.L., B.D.R., R.A.S., L.V.G., and S.M.D. analyzed data; K.A.L. and S.M.D. wrote the paper.

  • B. D. Rood’s present address: Department of Cell Biology and Neuroscience, Rowan University, Stratford, NJ 08084.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health National Institute on Drug Abuse Grant R01 DA034022 (to S.M.D.) and Blueprint Award NS108515 (to K.A.L.), the National Institute on Deafness and Other Communication Grant R01 DC015974 (to L.V.G.), and G.V.R. Khodadad Fund for studies of EPS (S.M.D.). K.A.L. was a Howard Hughes Medical Institute Gilliam Fellow.

Funding

  • HHS | National Institutes of Health (NIH)

    DA034022; NS108515; DC015974
  • G.V.R. Khodadad Fund for studies of EPS

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 19, 2020).

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Nov 20204080181
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Jul 20211910829
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Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior
Krissy A. Lyon, Benjamin D. Rood, Lorna Wu, Rebecca A. Senft, Lisa V. Goodrich, Susan M. Dymecki
eNeuro 19 November 2020, 7 (6) ENEURO.0202-20.2020; DOI: 10.1523/ENEURO.0202-20.2020

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Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior
Krissy A. Lyon, Benjamin D. Rood, Lorna Wu, Rebecca A. Senft, Lisa V. Goodrich, Susan M. Dymecki
eNeuro 19 November 2020, 7 (6) ENEURO.0202-20.2020; DOI: 10.1523/ENEURO.0202-20.2020
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Keywords

  • acoustic startle
  • dominance
  • dopamine receptor
  • raphe
  • serotonin
  • sex differences

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