Research ArticleResearch Article: New Research, Disorders of the Nervous System

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice

Nawshaba Nawreen, Evelin M. Cotella, Rachel Morano, Parinaz Mahbod, Khushali S. Dalal, Maureen Fitzgerald, Susan Martelle, Benjamin A. Packard, Ana Franco-Villanueva, Rachel D. Moloney and James P. Herman
eNeuro 14 October 2020, 7 (5) ENEURO.0423-19.2020; https://doi.org/10.1523/ENEURO.0423-19.2020

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0423-19.2020
PubMed 
33055196
Published By 
Society for Neuroscience
History 
  • Received October 7, 2019
  • Revision received August 24, 2020
  • Accepted September 30, 2020
  • Published online October 14, 2020.
Copyright & Usage 
Copyright © 2020 Nawreen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nawshaba Nawreen1,2,4,
  2. Evelin M. Cotella1,4,
  3. Rachel Morano1,
  4. Parinaz Mahbod1,
  5. Khushali S. Dalal3,
  6. Maureen Fitzgerald1,
  7. Susan Martelle1,
  8. Benjamin A. Packard1,4,
  9. Ana Franco-Villanueva1,
  10. Rachel D. Moloney1,4 and
  11. James P. Herman1,2,4,5
  1. 1Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45237-0506
  2. 2Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45237-0506
  3. 3College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH 45237-0506
  4. 4Veterans Affairs Medical Center, Cincinnati, OH 45221-0506
  5. 5Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45237-0506
  1. Correspondence should be addressed to James P. Herman at hermanjs{at}ucmail.uc.edu.

  • S. Martelle’s present address: Wake Forest Innovations, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States.

  • R. D. Moloney’s present address: School of Pharmacy, University College Cork, Cork, Ireland.

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Author contributions

  1. Author contributions: N.N., E.M.C., S.M., R.D.M., and J.P.H. designed research; N.N., R.M., P.M., K.S.D., M.F., and B.A.P. performed research; N.N. and A.F.-V. contributed unpublished reagents/analytic tools; N.N., E.M.C., and K.S.D. analyzed data; N.N. and J.P.H. wrote the paper.

  • S. Martelle’s present address: Wake Forest Innovations, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States.

  • R. D. Moloney’s present address: School of Pharmacy, University College Cork, Cork, Ireland.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Mental Health (NIMH) Grants R01-MH101729 and R01-MH048698 and by the United States Department of Veterans Affairs Grant I01BX003858 (to J.P.H.), NIMH Grants T32-NS-007453 and F31- MH123041 (to N.N.) and T32 DK059803 (to E.M.C.), Cohen Veterans Bioscience (S.M.), and a National Alliance for Research on Schizophrenia and Depression Young Investigator Award (R.D.M.).

Funding

  • NIH Training Grant

    T32-NS-007453-17; T32 DK059803

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01-MH101729 and R01-MH048698; F31- MH123041-01

  • National Alliance for Research on Schizophrenia and Depression (NARSAD)

    BBRF

  • U.S. Department of Veterans Affairs (VA)

    I01BX003858

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Online Impact

 

Article usage

Article usage: October 2020 to July 2025

AbstractFullPdf
Oct 20202086107355
Nov 2020211493136
Dec 20206226083
Total 20202359860574
Jan 20212725354
Feb 20211922735
Mar 20211818665
Apr 20211011836
May 2021711821
Jun 2021514438
Jul 2021611135
Aug 2021912549
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Total 20211231716482
Jan 2022811033
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Apr 202249426
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Jul 202207318
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Jul 202346936
Aug 2023148037
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Total 2023861173304
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Total 20242391720377
Jan 2025189746
Feb 202527920
Mar 202548922
Apr 2025186143
May 2025138419
Jun 2025128927
Jul 2025284
Total 202569507181
Total291469052223
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eneuro: 7 (5)
eNeuro
Vol. 7, Issue 5
September/October 2020
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Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice
Nawshaba Nawreen, Evelin M. Cotella, Rachel Morano, Parinaz Mahbod, Khushali S. Dalal, Maureen Fitzgerald, Susan Martelle, Benjamin A. Packard, Ana Franco-Villanueva, Rachel D. Moloney, James P. Herman
eNeuro 14 October 2020, 7 (5) ENEURO.0423-19.2020; DOI: 10.1523/ENEURO.0423-19.2020
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