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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior

Austin T. Akers, Skylar Y. Cooper, Zachary J. Baumgard, Gabriella P. Casinelli, Alicia J. Avelar and Brandon J. Henderson
eNeuro 28 September 2020, 7 (5) ENEURO.0189-20.2020; https://doi.org/10.1523/ENEURO.0189-20.2020
Austin T. Akers
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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Skylar Y. Cooper
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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  • ORCID record for Skylar Y. Cooper
Zachary J. Baumgard
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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Gabriella P. Casinelli
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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Alicia J. Avelar
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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Brandon J. Henderson
Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0189-20.2020
PubMed 
32988984
Published By 
Society for Neuroscience
History 
  • Received May 10, 2020
  • Revision received September 14, 2020
  • Accepted September 16, 2020
  • Published online September 28, 2020.
Copyright & Usage 
Copyright © 2020 Akers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Austin T. Akers,
  2. Skylar Y. Cooper,
  3. Zachary J. Baumgard,
  4. Gabriella P. Casinelli,
  5. Alicia J. Avelar and
  6. Brandon J. Henderson
  1. Department of Biomedical Sciences, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25703
  1. Correspondence should be addressed to Brandon J. Henderson at hendersonbr{at}marshall.edu.
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Author contributions

  1. Author contributions: B.J.H. designed research; A.T.A., S.Y.C., Z.J.B., G.P.C., A.J.A., and B.J.H. performed research; A.T.A., S.Y.C., Z.J.B., G.P.C., A.J.A., and B.J.H. analyzed data; B.J.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes on Drug Abuse at the National Institutes of Health Grant DA040047 (to B.J.H.). Research reported in this publication was supported by National Institute on Drug Abuse and Food and Drug Administration Center for Tobacco Products Grant DA046335 (to B.J.H.). Funding was also provided by the PhRMA Foundation (Predoctoral Fellowship in Pharmacology/Toxicology to S.Y.C.) and startup funds to B.J.H. by the Marshall University Research Corporation.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA040047; DA046335
  • Pharmaceutical Research and Manufacturers of America Foundation (PhRMA Foundation)

    Predoctoral Fellowship

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  • You are viewing the most recent version of this article.
  • previous version (September 28, 2020).

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Sep 202085026
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Nov 20206615035
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Total 2020829547289
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Apr 2021135612
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Jul 202513514
Total 202538466101
Total110736841162
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Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior
Austin T. Akers, Skylar Y. Cooper, Zachary J. Baumgard, Gabriella P. Casinelli, Alicia J. Avelar, Brandon J. Henderson
eNeuro 28 September 2020, 7 (5) ENEURO.0189-20.2020; DOI: 10.1523/ENEURO.0189-20.2020

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Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior
Austin T. Akers, Skylar Y. Cooper, Zachary J. Baumgard, Gabriella P. Casinelli, Alicia J. Avelar, Brandon J. Henderson
eNeuro 28 September 2020, 7 (5) ENEURO.0189-20.2020; DOI: 10.1523/ENEURO.0189-20.2020
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Keywords

  • excitability
  • nicotine
  • nicotinic receptor
  • reward
  • upregulation

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