Maternal Exposure to the Cannabinoid Agonist WIN 55,12,2 during Lactation Induces Lasting Behavioral and Synaptic Alterations in the Rat Adult Offspring of Both Sexes

Andrew F. Scheyer; Milene Borsoi; Anne-Laure Pelissier-Alicot; Olivier J.J. Manzoni

doi:10.1523/ENEURO.0144-20.2020

Article Information

DOI

https://doi.org/10.1523/ENEURO.0144-20.2020

PubMed

32868310

Published By

Society for Neuroscience

History

Received April 10, 2020
Revision received July 9, 2020
Accepted July 27, 2020
Published online August 31, 2020.

Copyright © 2020 Scheyer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

Andrew F. Scheyer¹,²,³,
Milene Borsoi¹,²,³,
Anne-Laure Pelissier-Alicot¹,²,³,⁴,⁵ and
Olivier J.J. Manzoni¹,²,³

¹Institut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale Unité 1249, Marseille, France
²Aix-Marseille University, France, 13273
³Cannalab Cannabinoids Neuroscience Research International Associated Laboratory, Institut National de la Santé et de la Recherche Médicale-Aix-Marseille University/Indiana University, 13273
⁴Service de Psychiatrie, Assistance Public Hopitaux de Marseille, Centre Hospitalier Universitaire Conception, Marseille 13005, France
⁵Service de Médecine Légale, APHM, CHU Timone Adultes, Marseille 13005, France

Correspondence should be addressed to Olivier J. J. Manzoni at olivier.manzoni{at}inserm.fr.

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Author contributions

Author contributions: A.F.S., M.B., A.-L.P.-A., and O.J.J.M. designed research; A.F.S. and M.B. performed research; A.F.S. and M.B. analyzed data; A.F.S. and O.J.J.M. wrote the paper.

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Disclosures

The authors declare no competing financial interests.
This work was supported by the Institut National de la Santé et de la Recherche Médicale (INSERM), the INSERM-National Institutes of Health (NIH) Exchange Program (A.F.S.), the Fondation pour la Recherche Médicale Grant Equipe FRM 2015 (to O.J.J.M.), and the NIH Grant R01DA043982 (to O.J.J.M.).