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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models

Dinesh Kumar Verma, Anurupa Ghosh, Lindsey Ruggiero, Etienne Cartier, Eric Janezic, Dionne Williams, Eui-Gil Jung, Michael Moore, Jong Bok Seo and Yong-Hwan Kim
eNeuro 4 September 2020, 7 (5) ENEURO.0134-20.2020; DOI: https://doi.org/10.1523/ENEURO.0134-20.2020
Dinesh Kumar Verma
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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  • ORCID record for Dinesh Kumar Verma
Anurupa Ghosh
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Lindsey Ruggiero
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Etienne Cartier
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Eric Janezic
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Dionne Williams
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Eui-Gil Jung
3Seoul Center, Korea Basic Science Institute, Seoul 02841, Republic of Korea
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Michael Moore
2Imaging Core, Delaware State University, Dover, DE 19901
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Jong Bok Seo
3Seoul Center, Korea Basic Science Institute, Seoul 02841, Republic of Korea
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Yong-Hwan Kim
1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0134-20.2020
PubMed 
32887693
Published By 
Society for Neuroscience
History 
  • Received April 2, 2020
  • Revision received July 20, 2020
  • Accepted July 21, 2020
  • Published online September 4, 2020.
Copyright & Usage 
Copyright © 2020 Verma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Dinesh Kumar Verma1,
  2. Anurupa Ghosh1,
  3. Lindsey Ruggiero1,
  4. Etienne Cartier1,
  5. Eric Janezic1,
  6. Dionne Williams1,
  7. Eui-Gil Jung3,
  8. Michael Moore2,
  9. Jong Bok Seo3 and
  10. Yong-Hwan Kim1
  1. 1Department of Biological Sciences/Neuroscience program, Delaware State University, Dover, DE 19901
  2. 2Imaging Core, Delaware State University, Dover, DE 19901
  3. 3Seoul Center, Korea Basic Science Institute, Seoul 02841, Republic of Korea
  1. Correspondence should be addressed to Dinesh Kumar Verma at dinesh.kr.v87{at}gmail.com or Yong-Hwan Kim at yhkim{at}desu.edu.
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Author contributions

  1. Author contributions: D.K.V., A.G., E.C., J.B.S., and Y.-H.K. designed research; D.K.V., A.G., L.R., E.C., E.J., D.W., and E.-G.J. performed research; Y.-H.K. contributed unpublished reagents/analytic tools; D.K.V., A.G., L.R., E.C., E.J., M.M., J.B.S., and Y.-H.K. analyzed data; D.K.V. and Y.-H.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grant 5P20GM103653 (to Y.-H.K.).

Funding

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    5P20GM103653

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The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models
Dinesh Kumar Verma, Anurupa Ghosh, Lindsey Ruggiero, Etienne Cartier, Eric Janezic, Dionne Williams, Eui-Gil Jung, Michael Moore, Jong Bok Seo, Yong-Hwan Kim
eNeuro 4 September 2020, 7 (5) ENEURO.0134-20.2020; DOI: 10.1523/ENEURO.0134-20.2020

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The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models
Dinesh Kumar Verma, Anurupa Ghosh, Lindsey Ruggiero, Etienne Cartier, Eric Janezic, Dionne Williams, Eui-Gil Jung, Michael Moore, Jong Bok Seo, Yong-Hwan Kim
eNeuro 4 September 2020, 7 (5) ENEURO.0134-20.2020; DOI: 10.1523/ENEURO.0134-20.2020
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Keywords

  • α-synuclein
  • degradation
  • lysosome
  • proteostasis
  • SUMOylation
  • Ubc9

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