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Research ArticleResearch Article: New Research, Disorders of the Nervous System

TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6

Julia Kaiser, Martina Maibach, Ester Piovesana, Iris Salpeter, Nora Escher, Yannick Ormen and Martin E. Schwab
eNeuro 4 September 2020, 7 (5) ENEURO.0104-20.2020; https://doi.org/10.1523/ENEURO.0104-20.2020
Julia Kaiser
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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  • ORCID record for Julia Kaiser
Martina Maibach
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Ester Piovesana
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Iris Salpeter
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Nora Escher
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Yannick Ormen
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Martin E. Schwab
1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0104-20.2020
PubMed 
32887692
Published By 
Society for Neuroscience
History 
  • Received March 17, 2020
  • Revision received July 21, 2020
  • Accepted August 6, 2020
  • Published online September 4, 2020.
Copyright & Usage 
Copyright © 2020 Kaiser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Julia Kaiser1,2,
  2. Martina Maibach1,2,
  3. Ester Piovesana1,2,
  4. Iris Salpeter1,2,
  5. Nora Escher1,2,
  6. Yannick Ormen1,2 and
  7. Martin E. Schwab1,2
  1. 1Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland
  2. 2Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland
  1. Correspondence should be addressed to Julia Kaiser at juk4004{at}med.cornell.edu.
  • M.E. Schwab’s present address: Institute of Regenerative Medicine, University of Zurich, CH-8057 Zurich, Switzerland.

  • J. Kaiser’s present address: Department of Neuroscience, Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains 10605, NY.

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Author contributions

  1. Author contributions: J.K., M.M., and M.E.S. designed research; J.K., M.M., E.P., I.S., N.E., and Y.O. performed research; J.K. and M.M. contributed unpublished reagents/analytic tools; J.K. and M.M. analyzed data; J.K., M.M., and M.E.S. wrote the paper.

  2. *J.K. and M.M. contributed equally to this work.

  • M.E. Schwab’s present address: Institute of Regenerative Medicine, University of Zurich, CH-8057 Zurich, Switzerland.

  • J. Kaiser’s present address: Department of Neuroscience, Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains 10605, NY.

Disclosures

  • M.E.S. is the cofounder and president of the board of NovaGo Therapeutics Inc. All other authors declare no competing financial interests.

  • This work was supported by the Swiss National Science Foundation Grant 3100A0-1222527-2], an Advanced European Research Council grant (Nogorise), and the Spinal Cord Consortium of the Christopher and Dana Reeve Foundation.

Funding

  • Swiss National Science Foundation

    3100A0-1222527-2
  • Advanced ERC grant (Nogorise)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 04, 2020).

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Sep 202031025152
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Total 2020876570329
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Jun 202137114
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Apr 20250956
May 20250677
Total 202594391143
Total137738711558
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eneuro: 7 (5)
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TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6
Julia Kaiser, Martina Maibach, Ester Piovesana, Iris Salpeter, Nora Escher, Yannick Ormen, Martin E. Schwab
eNeuro 4 September 2020, 7 (5) ENEURO.0104-20.2020; DOI: 10.1523/ENEURO.0104-20.2020

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TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6
Julia Kaiser, Martina Maibach, Ester Piovesana, Iris Salpeter, Nora Escher, Yannick Ormen, Martin E. Schwab
eNeuro 4 September 2020, 7 (5) ENEURO.0104-20.2020; DOI: 10.1523/ENEURO.0104-20.2020
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Keywords

  • downstream signaling
  • Neurite outgrowth
  • plasticity
  • stroke
  • tgfb1

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