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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine

Ekaterina Morozova, Philippe Faure, Boris Gutkin, Christoper Lapish and Alexey Kuznetsov
eNeuro 31 July 2020, 7 (4) ENEURO.0418-19.2020; https://doi.org/10.1523/ENEURO.0418-19.2020
Ekaterina Morozova
1Volen Center for Complex systems, Brandeis University, Waltham, Massachusetts 02453
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Philippe Faure
2Neuroscience Paris Seine—Institutde Biologie Paris Seine, INSERM, CNRS, Sorbonne Université, 75013 Paris, France
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Boris Gutkin
3Group for Neural Theory, LNC2 INSERMU960, Départment d’études cognitives, École Normale Supérieure, Université PSL, 75005 Paris, France
4Center for Cognition and Decision Making, Institute for Cognitive Neuroscience, National Research University Higher School of Economics, Moscow 101000, Russia
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Christoper Lapish
5Department of Psychology, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana 46204
7Indiana Alcohol Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46204
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Alexey Kuznetsov
6Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana 46204
7Indiana Alcohol Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46204
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0418-19.2020
PubMed 
32737187
Published By 
Society for Neuroscience
History 
  • Received October 10, 2019
  • Revision received February 10, 2020
  • Accepted April 18, 2020
  • Published online July 31, 2020.
Copyright & Usage 
Copyright © 2020 Morozova et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ekaterina Morozova1,
  2. Philippe Faure2,
  3. Boris Gutkin3,4,
  4. Christoper Lapish5,7 and
  5. Alexey Kuznetsov6,7
  1. 1Volen Center for Complex systems, Brandeis University, Waltham, Massachusetts 02453
  2. 2Neuroscience Paris Seine—Institutde Biologie Paris Seine, INSERM, CNRS, Sorbonne Université, 75013 Paris, France
  3. 3Group for Neural Theory, LNC2 INSERMU960, Départment d’études cognitives, École Normale Supérieure, Université PSL, 75005 Paris, France
  4. 4Center for Cognition and Decision Making, Institute for Cognitive Neuroscience, National Research University Higher School of Economics, Moscow 101000, Russia
  5. 5Department of Psychology, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana 46204
  6. 6Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana 46204
  7. 7Indiana Alcohol Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46204
  1. Correspondence should be addressed to Alexey Kuznetsov at askuznet{at}iupui.edu.
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Author contributions

  1. Author contributions: A.K. designed research; E.M. and A.K. performed research; E.M., P.F., B.G., C.L., and A.K. analyzed data; E.M., P.F., B.G., C.L., and A.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by French National Cancer Institute Grant TABAC-16–022 (to P.F.), the Agence Nationale de la Recherche, and the LabEx Bio-Psy (to P.F.).

Funding

  • French National Cancer Institute

    TABAC-16-022
  • Agence Nationale de la Recherche (ANR)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 31, 2020).

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AbstractFullPdf
Jul 20202004
Aug 20202312775
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Oct 20203119134
Nov 20202111722
Dec 20201911119
Total 2020402670229
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Apr 202184910
May 202166117
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Jul 202124610
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Total 202238497174
Jan 20230358
Feb 202312812
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Total 202563959284
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Feb 2026312210
Total 20261928332
Total64941951201
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Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine
Ekaterina Morozova, Philippe Faure, Boris Gutkin, Christoper Lapish, Alexey Kuznetsov
eNeuro 31 July 2020, 7 (4) ENEURO.0418-19.2020; DOI: 10.1523/ENEURO.0418-19.2020

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Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine
Ekaterina Morozova, Philippe Faure, Boris Gutkin, Christoper Lapish, Alexey Kuznetsov
eNeuro 31 July 2020, 7 (4) ENEURO.0418-19.2020; DOI: 10.1523/ENEURO.0418-19.2020
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Keywords

  • bursting
  • dopamine neuron
  • receptor knockout
  • receptor re-expression
  • saliency signal
  • synchrony

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