Skip to main content

Umbrella menu

  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

User menu

  • My alerts

Search

  • Advanced search
eNeuro
  • My alerts

eNeuro

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
PreviousNext
Research ArticleResearch Article: New Research, Cognition and Behavior

Infralimbic Cortex Biases Preference Decision Making for Offspring over Competing Cocaine-Associated Stimuli in New Mother Rats

Mariana Pereira and Joan I. Morrell
eNeuro 6 July 2020, 7 (4) ENEURO.0460-19.2020; DOI: https://doi.org/10.1523/ENEURO.0460-19.2020
Mariana Pereira
1Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, MA 01003,
2Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joan I. Morrell
2Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Figures

  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Effect of transient mPFC subregion-specific inactivation on preference decision making in a concurrent pup/cocaine choice CPP. A, Schematic representation of cross-sections of the rat brain showing the location of injection sites in mother rats receiving infusions of saline (white circles) or bupivacaine (inactivation, black circles) into each of three mPFC subregions. Numbers beside each plate indicate the distance caudal to bregma in millimeters. B, Experimental timeline. C, Locomotor scores during 1.0 mg/kg intraperitoneal cocaine conditioning in the CPP apparatus across the four conditioning days. D, CPP scores (time spent in the preferred compartment during the postconditioning test minus the time spent in the same compartment during the preconditioning session), (E) conditioned chamber preferences, and (F) mean time spent in each chamber of the CPP apparatus during the test session by behavioral control (n = 12), mPFC vehicle treated (n = 20), and mPFC Cg1 (n = 7), PrL (n = 7), and IL (n = 9) bupivacaine-treated postpartum females. Immediately before the start of the 60-min postconditioning CPP test, mPFC cannulated females randomly received bilateral intracranial infusions of either 2% bupivacaine or saline vehicle. Statistical analysis revealed that there was no significant difference in distribution of preference on concurrent pup/cocaine choice between postpartum females that received vehicle into Cg1, PrL, or IL subregions. As such, these groups were combined into a single vehicle-treated group for graphing purposes. Data are expressed as the mean ± SEM; *significant difference at p < 0.05.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Effect of transient mPFC subregion-specific inactivation on maternal behavior. A, Number of active maternal responses over the 30-min maternal behavior test following infusion of either 2% bupivacaine or saline vehicle into the Cg1, PrL, or IL. B, C, Latency to first retrieval and reunion of the litter, and (D) duration of total time with pups over the maternal behavior test. Data are expressed as the mean ± SEM; *significant difference at p < 0.05.

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Effect of transient inactivation of the mPFC subregion-specific on expression of cocaine-induced CPP. A, Schematic representation of cross-sections of the rat brain showing the location of injection sites in mother rats receiving infusions of saline (white circles) or bupivacaine (inactivation, black circles) into each of three mPFC subregions. Numbers beside each plate indicate the distance caudal to bregma in millimeters. B, Experimental timeline. C, CPP scores (time spent in the cocaine-associated compartment during the postconditioning test minus the time spent in the same compartment during the preconditioning session), (D) conditioned chamber preferences, and (E) mean time spent in each chamber of the CPP apparatus during the test session by behavioral control (n = 11), mPFC vehicle treated (n = 19), and mPFC Cg1 (n = 6), PrL (n = 7), and IL (n = 7) bupivacaine-treated postpartum females. All further details as in Figure 1. Data are expressed as the mean ± SEM; *significant difference at p < 0.05.

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    Effect of transient inactivation of the mPFC subregion-specific on expression of pup-induced CPP. A, Schematic representation of cross-sections of the rat brain showing the location of injection sites in mother rats receiving infusions of saline (white circles) or bupivacaine (inactivation, black circles) into each of three mPFC subregions. Numbers beside each plate indicate the distance caudal to bregma in millimeters. B, Experimental timeline. C, CPP score (time spent in the pup-associated compartment during the postconditioning test minus the time spent in the same compartment during the preconditioning session), (D) conditioned chamber preferences, and (E) mean time spent in each chamber of the CPP apparatus during the test session by behavioral control (n = 11), mPFC vehicle treated (n = 22), and mPFC Cg1 (n = 6), PrL (n = 8), and IL (n = 7) bupivacaine-treated postpartum females. All further details as in Figure 1. Data are expressed as the mean ± SEM; *significant difference at p < 0.05.

Back to top

In this issue

eneuro: 7 (4)
eNeuro
Vol. 7, Issue 4
July/August 2020
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Infralimbic Cortex Biases Preference Decision Making for Offspring over Competing Cocaine-Associated Stimuli in New Mother Rats
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Infralimbic Cortex Biases Preference Decision Making for Offspring over Competing Cocaine-Associated Stimuli in New Mother Rats
Mariana Pereira, Joan I. Morrell
eNeuro 6 July 2020, 7 (4) ENEURO.0460-19.2020; DOI: 10.1523/ENEURO.0460-19.2020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Infralimbic Cortex Biases Preference Decision Making for Offspring over Competing Cocaine-Associated Stimuli in New Mother Rats
Mariana Pereira, Joan I. Morrell
eNeuro 6 July 2020, 7 (4) ENEURO.0460-19.2020; DOI: 10.1523/ENEURO.0460-19.2020
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • addiction
  • conditioned place preference
  • maternal behavior
  • medial prefrontal cortex
  • postpartum period

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Context Memory Encoding and Retrieval Temporal Dynamics Are Modulated by Attention across the Adult Lifespan
  • Neural correlates of vocal auditory feedback processing: Unique insights from electrocorticography recordings in a human cochlear implant user
  • Group II Metabotropic Glutamate Receptors Modulate Sound Evoked and Spontaneous Activity in the Mouse Inferior Colliculus
Show more Research Article: New Research

Cognition and Behavior

  • Food-seeking behavior is mediated by Fos-expressing neuronal ensembles formed at first learning in rats
  • How to control behavioural studies for rodents – don’t project human thoughts onto them
  • Improved cognitive promotion through accelerated magnetic stimulation
Show more Cognition and Behavior

Subjects

  • Cognition and Behavior
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2021 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.