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Review, Disorders of the Nervous System

Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability

Alessandra Folci, Filippo Mirabella and Matteo Fossati
eNeuro 27 July 2020, 7 (4) ENEURO.0137-20.2020; https://doi.org/10.1523/ENEURO.0137-20.2020
Alessandra Folci
1Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano (MI), Italy
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Filippo Mirabella
2Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve 9 Emanuele – Milan, Italy
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Matteo Fossati
1Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano (MI), Italy
3CNR–Institute of Neuroscience, via Manzoni 56, 20089, Rozzano (MI), Italy
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0137-20.2020
PubMed 
32719102
Published By 
Society for Neuroscience
History 
  • Received April 7, 2020
  • Revision received June 8, 2020
  • Accepted June 17, 2020
  • Published online July 27, 2020.
Copyright & Usage 
Copyright © 2020 Folci et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alessandra Folci1,
  2. Filippo Mirabella2 and
  3. Matteo Fossati1,3
  1. 1Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano (MI), Italy
  2. 2Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve 9 Emanuele – Milan, Italy
  3. 3CNR–Institute of Neuroscience, via Manzoni 56, 20089, Rozzano (MI), Italy
  1. Correspondence should be addressed to Alessandra Folci at alessandra.folci{at}humanitasresearch.it or Matteo Fossati at matteo.fossati{at}in.cnr.it.
View Full Text

Author contributions

  1. Author contributions: F.M. prepared the figures and wrote the manuscript; A.F. and M.F. conceived and wrote the manuscript.

  2. *A.F. and M.F. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Italian Ministry of Health (GR-2018-12366478 to M.F.) and the European Union’s Horizon 2020 research and innovation programme (Marie Sklodowska-Curie grant agreement 845466 to A.F.).

Funding

  • Young Investigator Grant, Italian Ministry of Health

    GR-2018-12366478
  • Marie Curie-Sklodowska Grant, EU Horizon 2020 research and innovation program

    845466

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  • You are viewing the most recent version of this article.
  • previous version (July 27, 2020).

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Jul 2020129073
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Total 2020505711341
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Apr 20211812625
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Jul 20251813653
Aug 202589734
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Total92766392109
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eneuro: 7 (4)
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Vol. 7, Issue 4
July/August 2020
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Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability
Alessandra Folci, Filippo Mirabella, Matteo Fossati
eNeuro 27 July 2020, 7 (4) ENEURO.0137-20.2020; DOI: 10.1523/ENEURO.0137-20.2020

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Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability
Alessandra Folci, Filippo Mirabella, Matteo Fossati
eNeuro 27 July 2020, 7 (4) ENEURO.0137-20.2020; DOI: 10.1523/ENEURO.0137-20.2020
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Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Ubiquitination and UBL Pathways in Synapse Physiology
    • ID and Impairment of Ubiquitination and Sumoylation Pathways
    • Conclusions and Perspectives
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • intellectual disability
  • ubiquitination
  • SUMOylation
  • neddylation
  • synapse development
  • synapse function

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