Fig. 1D | Maximum migration speed | Normal | Unpaired t test | Control vs SP | p = 1.68E-10; t(20) = 11.86 | 0.0 | –54.2 [–63.1, –46.0] |
Fig. 1D | Mean migration speed | Normal | Unpaired t test | Control vs SP | p = 1.68E-09; t(20) = 10.38 | 0.0 | –28.1 [–33.8, –23.6] |
Fig. 1D | Minimum migration speed | Normal | Unpaired t test | Control vs SP | p = 0.0000717; t(20) = 4.98 | 0.0 | –4.68 [–6.76, –3.08] |
Fig. 1E | Speed variation | Normal | Unpaired t test | Control vs SP | p = 0.000188; t(20) = –4.56 | 0.0002 | 0.136 [0.0827, 0.196] |
Fig. 1F | Displacement | Normal | Unpaired t test | Control vs SP | p = 4.73E-07; t(20) = 7.29 | 0.0 | –81.2 [–1.06e+02, –63.6] |
Fig. 1G | Straightness | Normal | Unpaired t test | Control vs SP | p = 0.451; t(20) = 0.769 | 0.389 | –0.0282 [–0.0955, 0.03] |
Fig. 2C | Maximum leadingprocess length | Normal | Unpaired t test | Control vs SP | p = 0.977; t(18) = –0.0294 | 0.975 | 0.177 [–10.7, 11.7] |
Fig. 2C | Mean leading processlength | Normal | Unpaired t test | Control vs SP | p = 0.947; t(18) = 0.0668 | 0.947 | –0.257 [–6.85, 7.48] |
Fig. 2C | Minimum leadingprocess length | Normal | Unpaired t test | Control vs SP | p = 0.911; t(18) = –0.112 | 0.917 | 0.413 [–6.12, 7.32] |
Fig. 2D | Frequency of growthcone splits | Normal | Unpaired t test | Control vs SP | p = 0.0169; t(34) = 2.51 | 0.0146 | –0.681 [–1.13, –0.121] |
Fig. 2G | Frequency of side branches | Normal | Unpaired t test | Control vs SP | p = 0.900; t(34) = 0.126 | 0.897 | 0.0347 [–0.479, 0.499] |
Fig. 2H | Side branch duration | Normal | Unpaired t test | Control vs SP | p = 0.016; t(102) = 2.46 | 0.0124 | –7.58 [–14.2, –2.12] |
Fig. 3C | Nucleokinesis distance | Normal | Unpaired t test | Control vs SP | p = 2.36E-10; t(18) = 12.58 | 0.0 | –6.36 [–7.3, –5.42] |
Fig. 3D | Nucleokinesis frequency | Normal | Unpaired t test | Control vs SP | p = 1.92E-08; t(18) = 8.96 | 0.0 | –0.765 [–0.912, –0.598] |
Fig. 3E | Pause duration | Normal | Unpaired t test | Control vs SP | p = 1.45E-07; t(18) = –7.89 | 0.0 | 9.5 [7.44, 11.8] |
Fig. 3F | Soma-swelling distance | Normal | Unpaired t test | Control vs SP | p = 0.001698; t(18) = 3.68 | 0.0022 | –1.79 [–2.64, –0.824] |
Fig. 3G | Swelling duration | Normal | Unpaired t test | Control vs SP | p = 0.00047; t(14) = –4.53 | 0.0014 | 7.04 [4.33, 9.76] |
Fig. 4D | Maximum migration speed | Normal | Unpaired t test | WT vs cTKO | p = 0.981; t(23) = 0.0236 | 0.982 | –0.117 [–9.81, 9.2] |
Fig. 4D | Mean migration speed | Normal | Unpaired t test | WT vs cTKO | p = 0.105; t(23) = 1.69 | 0.11 | –5.59 [–12.0, 0.867] |
Fig. 4D | Minimum migration speed | Normal | Unpaired t test | WT vs cTKO | p = 0.260; t(23) = 1.16 | 0.256 | –1.24 [–3.27, 0.771] |
Fig. 4E | Speed variation | Normal | Unpaired t test | WT vs cTKO | p = 0.022; t(23) = –2.46 | 0.0208 | 0.057 [0.0166, 0.107] |
Fig. 4F | Displacement | Normal | Unpaired t test | WT vs cTKO | p = 0.048; t(23) = 2.09 | 0.0492 | –29.1 [–54.8, –0.875] |
Fig. 4G | Straightness | Normal | Unpaired t test | WT vs cTKO | p = 0.027; t(23) = 2.37 | 0.0284 | –0.0651 [–0.118, –0.0133] |
Fig. 4H | Frequency of growthcone splits | Normal | Unpaired t test | WT vs cTKO | p = 0.0454; t(20) = 2.13 | 0.0318 | –0.618 [–1.29, –0.183] |
Fig. 4I | Frequency of sidebranches | Normal | Unpaired t test | WT vs cTKO | p = 0.658; t(20) = 0.448 | 0.654 | –0.113 [–0.542, 0.385] |
Fig. 4J | Side branch duration | Normal | Unpaired t test | WT vs cTKO | p = 0.046; t(60) = 2.04 | 0.044 | –8.83 [–17.7, –1.83] |
Fig. 5C | Nucleokinesis distance | Normal | Unpaired t test | WT vs cTKO | p = 0.028; t(18) = 2.39 | 0.0298 | –0.92 [–1.61, –0.17] |
Fig. 5D | Nucleokinesis frequency | Normal | Unpaired t test | WT vs cTKO | p = 0.00203; t(18) = –3.60 | 0.0012 | 0.458 [0.262, 0.752] |
Fig. 5E | Pause duration | Normal | Unpaired t test | WT vs cTKO | p = 0.000464; t(18) = 4.27 | 0.0002 | –5.09 [–7.84, –3.27] |
Fig. 5F | Swelling duration | Normal | Unpaired t test | WT vs cTKO | p = 0.00257; t(10) = 3.99 | 0.0012 | –2.61 [–3.94, –1.54] |
Fig. 6D | Centrosome localization | Normal | Two-way ANOVA(post hoc Fisher’sexact test) | Control vs SP | p < 0.0001; F(2,114) = 13.82 | NA | NA |
Fig. 6E | Centrosome presencein swelling | Normal | χ2 | Control vs SP | p < 0.0001; Χ2(331.1, 1) =18.20 | NA | NA |
Fig. 6F | Centrosome maximumdistance forward | Normal | Unpaired t test | Control vs SP | p = 0.028; t(38) = 2.30 | 0.0256 | –3.2 [–5.82, –0.79] |
Fig. 6F | Centrosome maximumdistance behind | Normal | Unpaired t test | Control vs SP | p = 0.000015; t(38) = 4.97 | 0 | –10.3 [–14.6, –6.49] |
Fig. 7C | Cilia localization | Normal | Two-way ANOVA(post hoc Fisher'sexact test) | Control vs SP | p < 0.0001; F(2,114) = 12.13 | NA | NA |
Fig. 7D | Cilia presence in swelling | Normal | χ2 | Control vs SP | p < 0.0001; Χ2(314.2,1) = 17.72 | NA | NA |
Fig. 7E | Cilia maximum distanceforward | Normal | Unpaired t test | Control vs SP | p = 0.0094; t(38) = 2.76 | 0.0094 | –4.16 [–7.0, –1.61] |
Fig. 7E | Cilia maximum distance behind | Normal | Unpaired t test | Control vs SP | p = 0.017; t(38) = 2.51 | 0.0152 | –6.38 [–11.6, –1.97] |
Fig. 7F | Cilia length | Normal | Unpaired t test | Control vs SP | p = 0.558; t(30) = 0.592 | 0.575 | –0.0983 [–0.439, 0.195] |
Extended Data Fig. 1-1A | Mean migration speed all cells | Normal | Unpaired t test | Control vs SP | p = 4.65E-53; t(252) = 19.74 | 0.0 | –28.4 [–31.1, –25.5] |
Extended Data Fig. 1-1B | Maximum migration speed | Normal | Unpaired t test | Control vs SP | p = 0.0053; t(25) = 3.05 | 0.0042 | –24.0 [–41.8, –10.6] |
Extended Data Fig. 1-1B | Mean migration speed | Normal | Unpaired t test | Control vs SP | p = 0.559; t(25) = 0.592 | 0.545 | –0.299 [–1.28, 0.636] |
Extended Data Fig. 1-1B | Minimum migration speed | Normal | Unpaired t test | Control vs SP | p = 0.209; t(25) = –1.29 | 0.210 | 1.39 [–0.708, 3.25] |
Extended Data Fig. 1-1C | Speed variation | Normal | Unpaired t test | Control vs SP | p = 0.0038; t(25) = 3.19 | 0.0028 | –0.187 [–0.317, –0.0848] |
Extended Data Fig. 1-1D | Displacement | Normal | Unpaired t test | Control vs SP | p = 0.158; t(25) = –1.45 | 0.172 | 15.6 [–5.9, 35.7] |
Extended Data Fig. 1-1E | Straightness | Normal | Unpaired t test | Control vs SP | p = 0.146; t(25) = –1.49 | 0.162 | 0.104 [–0.0304, 0.238] |
Extended Data Fig. 1-1F | Soma-swelling distance | Normal | Unpaired t test | Control vs SP | p = 0.0017; t(25) = 3.51 | 0.0008 | –2.3 [–3.7, –1.19] |
Extended Data Fig. 1-1G | Average nucleokinesis distance | Normal | Unpaired t test | Control vs SP | p = 8.26E-06; t(25) = 5.58 | 0.0 | –3.94 [–5.36, –2.6] |
Extended Data Fig. 1-1H | <10-µm nucleokinesis distance | Normal | Unpaired t test | Control vs SP | p = 0.239; t(25) = –1.20 | 0.236 | 0.259 [–0.113, 0.719] |
Extended Data Fig. 1-1I | >10-µm nucleokinesis distance | Normal | Unpaired t test | Control vs SP | p = 0.00094; t(25) = 3.75 | 0.0004 | –2.73 [–4.26, –1.43] |
Extended Data Fig. 1-1J | Nucleokinesis frequency | Normal | Unpaired t test | Control vs SP | p = 0.382; t(25) = 0.890 | 0.381 | –0.111 [–0.345, 0.123] |
Extended Data Fig. 1-1K | Pause duration | Normal | Unpaired t test | Control vs SP | p = 0.805; t(25) = –0.250 | 0.805 | 0.363 [–2.62, 2.85] |
Extended Data Fig. 1-1L | >10-µm nucleokinesis frequency | Normal | Unpaired t test | Control vs SP | p = 0.087; t(25) = 1.78 | 0.098 | –0.233 [–0.458, 0.0489] |
Extended Data Fig. 1-1M | Frequency of growth cone splits | Normal | Unpaired t test | Control vs SP | p = 0.00398; t(8) = 3.99 | 0.0096 | –1.33 [–1.81, –0.612] |
Extended Data Fig. 1-1N | Frequency of side branches | Normal | Unpaired t test | Control vs SP | p = 0.324; t(8) = 1.05 | 0.329 | –0.44 [–1.1, 0.369] |
Extended Data Fig. 1-1O | Side branch duration | Normal | Unpaired t test | Control vs SP | p = 0.529; t(25) = 0.639 | 0.556 | –3.16 [–14.8, 4.59] |