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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi and Masato Koike
eNeuro 17 August 2020, 7 (4) ENEURO.0072-20.2020; https://doi.org/10.1523/ENEURO.0072-20.2020
Laxmi Kumar Parajuli
1Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
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Ken Wako
1Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
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Suiki Maruo
1Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
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Soichiro Kakuta
2Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
3Laboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
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Tomoyuki Taguchi
4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
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Masashi Ikuno
4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
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  • ORCID record for Masashi Ikuno
Hodaka Yamakado
4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
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Ryosuke Takahashi
4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
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Masato Koike
1Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
5Advanced Research Institute for Health Science, Juntendo University, Tokyo 113-8421, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0072-20.2020
PubMed 
32817196
Published By 
Society for Neuroscience
History 
  • Received February 27, 2020
  • Revision received August 12, 2020
  • Accepted August 12, 2020
  • Published online August 17, 2020.
Copyright & Usage 
Copyright © 2020 Parajuli et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Laxmi Kumar Parajuli1,
  2. Ken Wako1,
  3. Suiki Maruo1,
  4. Soichiro Kakuta2,3,
  5. Tomoyuki Taguchi4,
  6. Masashi Ikuno4,
  7. Hodaka Yamakado4,
  8. Ryosuke Takahashi4 and
  9. Masato Koike1,5
  1. 1Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
  2. 2Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
  3. 3Laboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
  4. 4Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
  5. 5Advanced Research Institute for Health Science, Juntendo University, Tokyo 113-8421, Japan
  1. Correspondence should be addressed to Masato Koike at mkoike{at}juntendo.ac.jp.
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Author contributions

  1. Author contributions: L.K.P. and M.K. designed research; L.K.P., K.W., S.M., S.K., T.T., and M.I. performed research; L.K.P. analyzed data; L.K.P. and M.K. wrote the paper; H.Y. and R.T. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Ministry of Education, Culture, Sports, Science, and Technology Grant-in-Aid for Scientific Research [A] JP18H04041 (to R.T.), Grant-in-Aid for Scientific Research [C] JP20K07743 (to M.K.), Grant-in-Aid for Early-Career Scientists 18K14842 (to L.K.P.), and Private School Branding Project (M.K.); the Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Japan Agency for Medical Research and Development (AMED) Grants JP18dm0207020 and JP19dm0207070 (to R.T.) and JP18dm0207024 (M.K.), the Japan Science and Technology Agency, CREST, Grant JP17gm0710011 (to R.T.), and the Mitsubishi Foundation Grant 29125 (to R.T.).

Funding

  • Grant-in-Aid for Early Career Scientists, KAKENHI

    18K14842
  • Grant-in-Aid for Scientific Research, KAKENHI [A]

    JP18H04041
  • Japan Agency for Medical Research and Development (AMED)

    JP18dm0207020;JP19dm0207070; JP18dm0207024
  • Japan Science and Technology Agency (JST)

    JP17gm0710011
  • Mitsubishi Foundation

    29125
  • Private School Branding Project

  • Grant-in-Aid for Scientific Research, KAKENHI [C]

    JP20K07743

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 17, 2020).

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Aug 2020426185206
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Total 20255951897
Total154047721422
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Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masato Koike
eNeuro 17 August 2020, 7 (4) ENEURO.0072-20.2020; DOI: 10.1523/ENEURO.0072-20.2020

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Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masato Koike
eNeuro 17 August 2020, 7 (4) ENEURO.0072-20.2020; DOI: 10.1523/ENEURO.0072-20.2020
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Keywords

  • α-synuclein
  • A53T
  • dendrite
  • dendritic spines
  • FIB/SEM
  • Parkinson’s disease

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