Article Figures & Data
Figures
- Figure 1.
Task and experimental conditions. First row, Early injection condition. Second row, Late injection condition. Third row, Control condition. Fourth row, Local anesthesia condition. In all conditions, subjects learned a list of semantically unrelated and emotionally neutral words. In the early injection condition, subjects received general anesthesia with propofol ∼13 min following learning and were tested for recall and recognition about 3 h after learning. In the late injection condition, subjects received general anesthesia ∼105 min after learning and were tested ∼4.5 h after learning. In the control condition, subjects received no anesthesia and were tested 3 h after learning. In the local anesthesia condition, subjects received local anesthesia and were tested 3 h after learning.
- Figure 2.
Results. A, Free recall immediately after initial learning of target word list and after learning of a distractor word list. B, Delayed free recall of target word list. C, Delayed corrected recognition of target word list (hits minus false alarms). Bars show median percent correct responses in four experimental conditions. Purple, propofol injection conditions; gray, control conditions. No A., no anesthesia; Loc. A., local anesthesia; ***p ≤ 0.001 difference between conditions, two-tailed Mann–Whitney test. Note selective performance decrease for recall in the early injection condition.
Tables
Early injection Late injection Control, no anesthesia Control, local anesthesia n 24 24 24 24 Female/male 13/11 13/11 12/12 11/13 Age (years) 35.5 (27–45) 36.5 (31–47) 38.5 (25–46.25) 35 (29.25–46) Years of education 13.75 (12.25–18) 14 (12–16) 16 (15–18) 15 (12–17) Medical procedure Strabismus surgery (n = 24) Strabismus surgery (n = 24) n.a. Nevus excision (n = 13); muscle/nerve biopsy (n = 6);removal of ostheosynthetic material (n = 5) Propofol bolus dose (mg) 200 (200–215) 200 (155–237.5) n.a. n.a. Propofol maintenance dose (mg/kg/h) 6 (6–6) 6 (6–6.75) n.a. n.a. Remifentanil dose (μ;g/kg/h) 0.2 (0.15–0.2) 0.2 (0.2–0.2) n.a. n.a. Delay end of learning and Propofol (min) 13 (10–17) 105 (95.25–115) n.a. n.a. Duration anesthesia (min) 58 (53–65) 56 (46.25–64.75) n.a. n.a. Delay end of anesthesia and testing (min) 113.5 (106.5–128) 113 (108.5–116.75) n.a. n.a. Delay end of learning and testing (min) 189.5 (175.75–205) 271 (261.25–289.5) 180 (180–180) 180 (150–180) Values are medians and interquartile ranges; n.a., not applicable.
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