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Research ArticleResearch Article: New Research, Cognition and Behavior

Propofol Modulates Early Memory Consolidation in Humans

Daa Un Moon, Nazli Esfahani-Bayerl, Carsten Finke, Daniel J. Salchow, Mario Menk, Simon Bayerl, Richard Kempter and Christoph J. Ploner
eNeuro 15 April 2020, 7 (3) ENEURO.0537-19.2020; DOI: https://doi.org/10.1523/ENEURO.0537-19.2020
Daa Un Moon
1Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
2Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin D-10117, Germany
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Nazli Esfahani-Bayerl
2Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin D-10117, Germany
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Carsten Finke
1Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
3Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin D-10117, Germany
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Daniel J. Salchow
4Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
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Mario Menk
5Department of Anesthesiology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
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Simon Bayerl
6Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Berlin D-10117, Germany
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Richard Kempter
7Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin D-10115, Germany
8Bernstein Center for Computational Neuroscience, Berlin D-10115, Germany
9Einstein Center for Neurosciences, Berlin D-10117, Germany
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Christoph J. Ploner
1Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0537-19.2020
PubMed 
32295771
Published By 
Society for Neuroscience
History 
  • Received December 20, 2019
  • Revision received March 21, 2020
  • Accepted March 23, 2020
  • Published online April 15, 2020.
Copyright & Usage 
Copyright © 2020 Moon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Daa Un Moon1,2,*,
  2. Nazli Esfahani-Bayerl2,*,
  3. Carsten Finke1,3,
  4. Daniel J. Salchow4,
  5. Mario Menk5,
  6. Simon Bayerl6,
  7. Richard Kempter7,8,9 and
  8. Christoph J. Ploner1
  1. 1Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
  2. 2Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin D-10117, Germany
  3. 3Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin D-10117, Germany
  4. 4Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
  5. 5Department of Anesthesiology, Charité – Universitätsmedizin Berlin, Berlin D-13353, Germany
  6. 6Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Berlin D-10117, Germany
  7. 7Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin D-10115, Germany
  8. 8Bernstein Center for Computational Neuroscience, Berlin D-10115, Germany
  9. 9Einstein Center for Neurosciences, Berlin D-10117, Germany
  1. Correspondence should be addressed to Christoph J. Ploner at christoph.ploner{at}charite.de.
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Author contributions

  1. Author contributions: C.J.P. designed research; D.U.M. and N.E.-B. performed research; D.J.S., M.M., and S.B. contributed unpublished reagents/analytic tools; D.U.M., N.E.-B., C.F., R.K., and C.J.P. analyzed data; D.U.M., C.F., R.K., and C.J.P. wrote the paper.

  2. ↵* D.U.M. and N.E.-B. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project number 327654276 – SFB 1315.

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    SFB 1315; SFB 1315

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  • previous version (April 15, 2020).

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Propofol Modulates Early Memory Consolidation in Humans
Daa Un Moon, Nazli Esfahani-Bayerl, Carsten Finke, Daniel J. Salchow, Mario Menk, Simon Bayerl, Richard Kempter, Christoph J. Ploner
eNeuro 15 April 2020, 7 (3) ENEURO.0537-19.2020; DOI: 10.1523/ENEURO.0537-19.2020

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Propofol Modulates Early Memory Consolidation in Humans
Daa Un Moon, Nazli Esfahani-Bayerl, Carsten Finke, Daniel J. Salchow, Mario Menk, Simon Bayerl, Richard Kempter, Christoph J. Ploner
eNeuro 15 April 2020, 7 (3) ENEURO.0537-19.2020; DOI: 10.1523/ENEURO.0537-19.2020
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Keywords

  • general anesthesia
  • hippocampus
  • Memory consolidation
  • propofol
  • synaptic consolidation
  • systems consolidation

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