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Research ArticleResearch Article: New Research, Neuronal Excitability

Hippocampal Synaptic Dysfunction in a Mouse Model of Huntington Disease Is Not Alleviated by Ceftriaxone Treatment

Crystal M. Wilkie, Jocelyn R. Barnes, Cherry-Lynn M. Benson, Kyle J. Brymer, Firoozeh Nafar and Matthew P. Parsons
eNeuro 30 April 2020, 7 (3) ENEURO.0440-19.2020; https://doi.org/10.1523/ENEURO.0440-19.2020
Crystal M. Wilkie
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Jocelyn R. Barnes
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Cherry-Lynn M. Benson
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Kyle J. Brymer
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Firoozeh Nafar
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Matthew P. Parsons
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0440-19.2020
PubMed 
32354757
Published By 
Society for Neuroscience
History 
  • Received October 25, 2019
  • Revision received April 21, 2020
  • Accepted April 22, 2020
  • Published online April 30, 2020.
Copyright & Usage 
Copyright © 2020 Wilkie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Crystal M. Wilkie,
  2. Jocelyn R. Barnes,
  3. Cherry-Lynn M. Benson,
  4. Kyle J. Brymer,
  5. Firoozeh Nafar and
  6. Matthew P. Parsons
  1. Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, Newfoundland A1B 3V6, Canada
  1. Correspondence should be addressed to Matthew P. Parsons at matthew.parsons{at}med.mun.ca.
View Full Text

Author contributions

  1. Author contributions: C.M.W., J.R.B., and M.P.P. designed research; C.M.W., J.R.B., C.M.B., K.J.B., and F.N. performed research; C.M.W., J.R.B., C.M.B., and M.P.P. analyzed data; C.M.W., J.R.B., and M.P.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by funding from the following sources: a Natural Sciences and Engineering Research Council of Canada Discovery Grant; a Huntington Society of Canada Navigator Grant; and an Epilepsy NL Research Grant.

Funding

  • Huntington's Society of Canada

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

  • Epilepsy Newfoundland and Labrador

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 30, 2020).

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Total100643061141
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Hippocampal Synaptic Dysfunction in a Mouse Model of Huntington Disease Is Not Alleviated by Ceftriaxone Treatment
Crystal M. Wilkie, Jocelyn R. Barnes, Cherry-Lynn M. Benson, Kyle J. Brymer, Firoozeh Nafar, Matthew P. Parsons
eNeuro 30 April 2020, 7 (3) ENEURO.0440-19.2020; DOI: 10.1523/ENEURO.0440-19.2020

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Hippocampal Synaptic Dysfunction in a Mouse Model of Huntington Disease Is Not Alleviated by Ceftriaxone Treatment
Crystal M. Wilkie, Jocelyn R. Barnes, Cherry-Lynn M. Benson, Kyle J. Brymer, Firoozeh Nafar, Matthew P. Parsons
eNeuro 30 April 2020, 7 (3) ENEURO.0440-19.2020; DOI: 10.1523/ENEURO.0440-19.2020
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Keywords

  • GLT-1
  • glutamate
  • glutamate uptake
  • Huntington's disease
  • iGluSnFR
  • plasticity

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