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Research ArticleResearch Article: New Research, Cognition and Behavior

Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal

Sierra Simpson, Adam Kimbrough, Brent Boomhower, Rio McLellan, Marcella Hughes, Kokila Shankar, Giordano de Guglielmo and Olivier George
eNeuro 27 April 2020, 7 (3) ENEURO.0312-19.2020; https://doi.org/10.1523/ENEURO.0312-19.2020
Sierra Simpson
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
2Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Adam Kimbrough
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
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Brent Boomhower
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
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Rio McLellan
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
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Marcella Hughes
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
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Kokila Shankar
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
2Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Giordano de Guglielmo
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
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Olivier George
1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
2Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0312-19.2020
PubMed 
32341122
Published By 
Society for Neuroscience
History 
  • Received August 6, 2019
  • Revision received February 26, 2020
  • Accepted March 24, 2020
  • Published online April 27, 2020.
Copyright & Usage 
Copyright © 2020 Simpson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sierra Simpson1,2,
  2. Adam Kimbrough1,
  3. Brent Boomhower1,
  4. Rio McLellan1,
  5. Marcella Hughes1,
  6. Kokila Shankar1,2,
  7. Giordano de Guglielmo1 and
  8. Olivier George1,2
  1. 1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093,
  2. 2Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037
  1. Correspondence should be addressed to Olivier George at olgeorge{at}health.ucsd.edu.
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Author contributions

  1. Author contributions: S.S., G.d.G., and O.G. designed research; S.S., B.B., R.M., M.H., and K.S. performed research; S.S. and A.K. analyzed data; S.S. and O.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants DA044451, DA043799, AA026081, and AA027301.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA044451; DA043799
  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    AA026081; AA027301

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 27, 2020).

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May 20201145371470
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Total 202524419113
Total174272122353
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Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal
Sierra Simpson, Adam Kimbrough, Brent Boomhower, Rio McLellan, Marcella Hughes, Kokila Shankar, Giordano de Guglielmo, Olivier George
eNeuro 27 April 2020, 7 (3) ENEURO.0312-19.2020; DOI: 10.1523/ENEURO.0312-19.2020

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Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal
Sierra Simpson, Adam Kimbrough, Brent Boomhower, Rio McLellan, Marcella Hughes, Kokila Shankar, Giordano de Guglielmo, Olivier George
eNeuro 27 April 2020, 7 (3) ENEURO.0312-19.2020; DOI: 10.1523/ENEURO.0312-19.2020
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Keywords

  • addiction
  • dependence
  • FOS
  • gut-brain axis
  • microbiome
  • opioids

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