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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice

Mayara C. Ribeiro, Seth M. Moore, Noriyuki Kishi, Jeffrey D. Macklis and Jessica L. MacDonald
eNeuro 11 May 2020, 7 (3) ENEURO.0167-20.2020; https://doi.org/10.1523/ENEURO.0167-20.2020
Mayara C. Ribeiro
1Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, NY 13244
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Seth M. Moore
1Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, NY 13244
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Noriyuki Kishi
2Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138
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Jeffrey D. Macklis
2Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138
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Jessica L. MacDonald
1Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, NY 13244
2Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0167-20.2020
PubMed 
32393583
Published By 
Society for Neuroscience
History 
  • Received April 29, 2020
  • Accepted April 30, 2020
  • Published online May 11, 2020.
Copyright & Usage 
Copyright © 2020 Ribeiro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mayara C. Ribeiro1,
  2. Seth M. Moore1,
  3. Noriyuki Kishi2,
  4. Jeffrey D. Macklis2,* and
  5. Jessica L. MacDonald1,2,*
  1. 1Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, NY 13244
  2. 2Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA 02138
  1. Correspondence should be addressed to Jessica L. MacDonald at jemacdon{at}syr.edu or Jeffrey D. Macklis at jeffrey_macklis{at}harvard.edu.
  • N. Kishi’s present address: Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Saitama 351-0198, Japan.

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Author contributions

  1. Author contributions: M.C.R., S.M.M., N.K., J.D.M., and J.L.M. designed research; M.C.R., S.M.M., and J.L.M. performed research; M.C.R. and J.L.M. analyzed data; M.C.R., J.D.M., and J.L.M. wrote the paper.

  2. ↵* J.D.M. and J.L.M. are co-senior authors.

  • N. Kishi’s present address: Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Saitama 351-0198, Japan.

Disclosures

  • The authors declare no competing financial interests.

  • This work is based on preliminary data obtained with seed funding from the Rett Syndrome Research Trust (J.D.M.) and was partially supported by the National Institutes of Health (NIH) Director’s Pioneer Award DP1 NS106665 (to J.D.M.), the Emily and Robert Pearlstein Fund (J.D.M.), and the Max and Anne Wien Professorship (J.D.M.). This work was also supported by the NIH/National Institute of Neurological Disorders and Stroke Grant 1R01NS106285 (to J.L.M.), the International Rett Syndrome Foundation Grant 3604 (to J.L.M.), and the Syracuse University Collaboration for Unprecedented Success and Excellence Grant Program (J.L.M.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    1R01NS106285
  • International Rett Syndrome Foundation (IRSF)

    3604
  • Syracuse University Collaboration for Unprecedented Success and Excellence Grant Program

  • Rett Syndrome Research Trust

  • NIH Director's Pioneer Award

    DP1 NS106665
  • Emily and Robert Perlstein Fund

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 11, 2020).

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May 2020753271213
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Aug 202576615
Sep 20251114622
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Total 202568924226
Total181254101690
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Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice
Mayara C. Ribeiro, Seth M. Moore, Noriyuki Kishi, Jeffrey D. Macklis, Jessica L. MacDonald
eNeuro 11 May 2020, 7 (3) ENEURO.0167-20.2020; DOI: 10.1523/ENEURO.0167-20.2020

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Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice
Mayara C. Ribeiro, Seth M. Moore, Noriyuki Kishi, Jeffrey D. Macklis, Jessica L. MacDonald
eNeuro 11 May 2020, 7 (3) ENEURO.0167-20.2020; DOI: 10.1523/ENEURO.0167-20.2020
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Keywords

  • epigenetics
  • neocortex
  • neuronal morphology
  • NF-κB
  • Rett Syndrome
  • vitamin D

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