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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain

Sheng Wang, Chao Bian, Jiale Yang, Vipin Arora, Yiwei Gao, Feng Wei and Man-Kyo Chung
eNeuro 13 May 2020, 7 (3) ENEURO.0118-20.2020; https://doi.org/10.1523/ENEURO.0118-20.2020
Sheng Wang
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Chao Bian
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Jiale Yang
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Vipin Arora
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Yiwei Gao
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Feng Wei
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Man-Kyo Chung
Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0118-20.2020
PubMed 
32404326
Published By 
Society for Neuroscience
History 
  • Received March 27, 2020
  • Revision received April 29, 2020
  • Accepted May 7, 2020
  • Published online May 13, 2020.
Copyright & Usage 
Copyright © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sheng Wang,
  2. Chao Bian,
  3. Jiale Yang,
  4. Vipin Arora,
  5. Yiwei Gao,
  6. Feng Wei and
  7. Man-Kyo Chung
  1. Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201
  1. Correspondence should be addressed to Man-Kyo Chung at mchung{at}umaryland.edu.
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Author contributions

  1. Author contributions: S.W., C.B., J.Y., F.W., and M.-K.C. designed research; S.W., C.B., J.Y., V.A., and Y.G. performed research; S.W., C.B., J.Y., V.A., Y.G., F.W., and M.-K.C. analyzed data; C.B., F.W., and M.-K.C. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants DE023846 (to M.-K.C.) and DE027731 (to M.-K.C. and F.W.).

Funding

  • HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

    023846; 027731

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 13, 2020).

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May 202045658231
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Total190265712463
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Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain
Sheng Wang, Chao Bian, Jiale Yang, Vipin Arora, Yiwei Gao, Feng Wei, Man-Kyo Chung
eNeuro 13 May 2020, 7 (3) ENEURO.0118-20.2020; DOI: 10.1523/ENEURO.0118-20.2020

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Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain
Sheng Wang, Chao Bian, Jiale Yang, Vipin Arora, Yiwei Gao, Feng Wei, Man-Kyo Chung
eNeuro 13 May 2020, 7 (3) ENEURO.0118-20.2020; DOI: 10.1523/ENEURO.0118-20.2020
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Keywords

  • analgesia
  • capsaicin
  • neuropathic pain
  • orofacial pain
  • TRPV1

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