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Research ArticleResearch Article: Confirmation, Disorders of the Nervous System

Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity

Leah C. Graham, Heidi E. Kocalis, Ileana Soto and Gareth R. Howell
eNeuro 9 April 2020, 7 (3) ENEURO.0057-20.2020; https://doi.org/10.1523/ENEURO.0057-20.2020
Leah C. Graham
1The Jackson Laboratory, Bar Harbor, ME 04609
2Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111
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  • ORCID record for Leah C. Graham
Heidi E. Kocalis
1The Jackson Laboratory, Bar Harbor, ME 04609
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Ileana Soto
3Department of Molecular & Cellular Biology, Rowan University, Glassboro, NJ 08028
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Gareth R. Howell
1The Jackson Laboratory, Bar Harbor, ME 04609
2Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111
4Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, MA 04469
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0057-20.2020
PubMed 
32273396
Published By 
Society for Neuroscience
History 
  • Received February 17, 2020
  • Accepted February 22, 2020
  • Published online April 9, 2020.
Copyright & Usage 
Copyright © 2020 Graham et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Leah C. Graham1,2,
  2. Heidi E. Kocalis1,
  3. Ileana Soto3 and
  4. Gareth R. Howell1,2,4
  1. 1The Jackson Laboratory, Bar Harbor, ME 04609
  2. 2Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111
  3. 3Department of Molecular & Cellular Biology, Rowan University, Glassboro, NJ 08028
  4. 4Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, MA 04469
  1. Correspondence should be addressed to Gareth R. Howell at gareth.howell{at}jax.org.
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Author contributions

  1. Author contributions: L.C.G. and G.R.H. designed research; L.C.G., H.E.K., I.S., and G.R.H. performed research; L.C.G., H.E.K., I.S., and G.R.H. analyzed data; L.C.G., H.E.K., I.S., and G.R.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes on Aging Grant RF1 AG051496 (to G.R.H.).

Funding

  • HHS | NIH | National Institute on Aging (NIA)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 09, 2020).

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AbstractFullPdf
May 2020177095
Jun 202063133132
Jul 20202310376
Aug 20202010546
Sep 20201410551
Oct 20201110322
Nov 202089715
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Total 2020325752472
Jan 202138622
Feb 202145113
Mar 202157124
Apr 202165515
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Jul 202126528
Aug 202166734
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Apr 202235121
May 202215842
Jun 202225929
Jul 202223927
Aug 202204435
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Total 202221607350
Jan 202325938
Feb 202314724
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Apr 202304926
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Jun 202305124
Jul 202346333
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Apr 2024613328
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Jul 202465618
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Total 202470752271
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Mar 202558630
Apr 202566317
May 202566239
Jun 2025117225
Jul 2025710937
Aug 202597633
Sep 20251121530
Oct 20251110430
Nov 2025138720
Dec 20251512437
Total 20251021157332
Jan 20261649
Total 20261649
Total60347782124
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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity
Leah C. Graham, Heidi E. Kocalis, Ileana Soto, Gareth R. Howell
eNeuro 9 April 2020, 7 (3) ENEURO.0057-20.2020; DOI: 10.1523/ENEURO.0057-20.2020

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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity
Leah C. Graham, Heidi E. Kocalis, Ileana Soto, Gareth R. Howell
eNeuro 9 April 2020, 7 (3) ENEURO.0057-20.2020; DOI: 10.1523/ENEURO.0057-20.2020
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Keywords

  • complement
  • microglia
  • mouse
  • myelin
  • obesity
  • vasculature

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