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Research ArticleResearch article: New Research, Disorders of the Nervous System

A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia

Alejandra Arias-Cavieres, Maggie A. Khuu, Chinwendu U. Nwakudu, Jasmine E. Barnard, Gokhan Dalgin and Alfredo J. Garcia III
eNeuro 3 June 2020, 7 (3) ENEURO.0024-20.2020; DOI: https://doi.org/10.1523/ENEURO.0024-20.2020
Alejandra Arias-Cavieres
1Institute for Integrative Physiology, The University of Chicago, Chicago, IL 60637
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Maggie A. Khuu
3Department of Medicine, Section of Emergency Medicine, The University of Chicago, Chicago, IL 60637
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Chinwendu U. Nwakudu
3Department of Medicine, Section of Emergency Medicine, The University of Chicago, Chicago, IL 60637
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Jasmine E. Barnard
3Department of Medicine, Section of Emergency Medicine, The University of Chicago, Chicago, IL 60637
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Gokhan Dalgin
4Department of Medicine Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL 60637
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Alfredo J. Garcia III
1Institute for Integrative Physiology, The University of Chicago, Chicago, IL 60637
2Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL 60637
3Department of Medicine, Section of Emergency Medicine, The University of Chicago, Chicago, IL 60637
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0024-20.2020
PubMed 
32493757
Published By 
Society for Neuroscience
History 
  • Received January 24, 2020
  • Revision received April 30, 2020
  • Accepted May 15, 2020
  • Published online June 3, 2020.
Copyright & Usage 
Copyright © 2020 Arias-Cavieres et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alejandra Arias-Cavieres1,
  2. Maggie A. Khuu3,
  3. Chinwendu U. Nwakudu3,
  4. Jasmine E. Barnard3,
  5. Gokhan Dalgin4 and
  6. Alfredo J. Garcia III1,2,3
  1. 1Institute for Integrative Physiology, The University of Chicago, Chicago, IL 60637
  2. 2Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL 60637
  3. 3Department of Medicine, Section of Emergency Medicine, The University of Chicago, Chicago, IL 60637
  4. 4Department of Medicine Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL 60637
  1. Correspondence should be addressed to Alfredo J. Garcia at ajgarcia3{at}uchicago.edu.
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Author contributions

  1. Author contributions: A.A.-C. and A.J.G. designed research; A.A.-C., M.A.K., C.U.N., J.E.B., G.D., and A.J.G. performed research; A.J.G. contributed unpublished reagents/analytic tools; A.A.-C., M.A.K., C.U.N., J.E.B., G.D., and A.J.G. analyzed data; A.A.-C., M.A.K., and A.J.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants PO 1 HL 144454 and R01 NS10742101 (to A.J.G.) and by a grant from The BSD Office of Diversity & Inclusion at The University of Chicago (A.J.G.). G.D. was also supported by The University of Chicago Diabetes Research Center Grant P30 DK020595.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS107421
  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    PO 1 HL 144454
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    P30 DK020595
  • The University of Chicago

    The BSD Office of Diversity & Inclusion Grant

Other Version

  • previous version (June 03, 2020).
  • You are viewing the most recent version of this article.

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Jun 2020685260146
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Aug 20204516752
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Oct 20201712231
Nov 2020248623
Dec 2020512928
Total 202010701197380
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Feb 2021210911
Mar 202199428
Apr 202168120
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A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia
Alejandra Arias-Cavieres, Maggie A. Khuu, Chinwendu U. Nwakudu, Jasmine E. Barnard, Gokhan Dalgin, Alfredo J. Garcia
eNeuro 3 June 2020, 7 (3) ENEURO.0024-20.2020; DOI: 10.1523/ENEURO.0024-20.2020

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A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia
Alejandra Arias-Cavieres, Maggie A. Khuu, Chinwendu U. Nwakudu, Jasmine E. Barnard, Gokhan Dalgin, Alfredo J. Garcia
eNeuro 3 June 2020, 7 (3) ENEURO.0024-20.2020; DOI: 10.1523/ENEURO.0024-20.2020
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Keywords

  • hypoxia inducible factor
  • NADPH oxidase
  • NMDA receptor
  • oxidative stress
  • sleep apnea

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