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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Epileptor Model: A Systematic Mathematical Analysis Linked to the Dynamics of Seizures, Refractory Status Epilepticus, and Depolarization Block

Kenza El Houssaini, Christophe Bernard and Viktor K. Jirsa
eNeuro 17 February 2020, 7 (2) ENEURO.0485-18.2019; https://doi.org/10.1523/ENEURO.0485-18.2019
Kenza El Houssaini
Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France
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Christophe Bernard
Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France
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  • ORCID record for Christophe Bernard
Viktor K. Jirsa
Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0485-18.2019
PubMed 
32066612
Published By 
Society for Neuroscience
History 
  • Received December 10, 2018
  • Revision received October 10, 2019
  • Accepted October 28, 2019
  • Published online February 17, 2020.
Copyright & Usage 
Copyright © 2020 El Houssaini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kenza El Houssaini,
  2. Christophe Bernard and
  3. Viktor K. Jirsa
  1. Aix Marseille University, INSERM, INS, Institut de Neurosciences des Systèmes, 13005 Marseille, France
  1. Correspondence should be addressed to Viktor K. Jirsa at viktor.jirsa{at}univ-amu.fr.
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Author contributions

  1. Author contributions: K.E.H. and V.K.J. designed research; K.E.H. performed research; K.E.H. analyzed data; K.E.H., C.B., and V.K.J. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research received financial support from the following agencies: Fondation pour la Recherche Médicale (Grant DIC20161236442 to Viktor K. Jirsa), European Commission’s Human Brain Project (Grant H2020-720270), and the SATT Sud-Est (TVB-Epilepsy). The work has been carried out within the FHU (Fédération Hospitalo-Universitaire) EPINEXT (Epilepsy and Disorders of Neuronal Excitability) with the support of the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the “Investissements d'Avenir” French Governement program managed by the French National Research Agency (ANR).

Funding

  • Fondation pour la Recherche Médicale (FRM)

    DIC20161236442
  • European Commission's Brain Project

    H2020-720270
  • Federation Hospitalo-Universitaire (FHU)

    ANR-11-IDEX-0001-02

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 17, 2020).

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Feb 2020225089
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Total 20261618152
Total116884812917
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eneuro: 7 (2)
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March/April 2020
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The Epileptor Model: A Systematic Mathematical Analysis Linked to the Dynamics of Seizures, Refractory Status Epilepticus, and Depolarization Block
Kenza El Houssaini, Christophe Bernard, Viktor K. Jirsa
eNeuro 17 February 2020, 7 (2) ENEURO.0485-18.2019; DOI: 10.1523/ENEURO.0485-18.2019

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The Epileptor Model: A Systematic Mathematical Analysis Linked to the Dynamics of Seizures, Refractory Status Epilepticus, and Depolarization Block
Kenza El Houssaini, Christophe Bernard, Viktor K. Jirsa
eNeuro 17 February 2020, 7 (2) ENEURO.0485-18.2019; DOI: 10.1523/ENEURO.0485-18.2019
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Keywords

  • bifurcation analysis
  • depolarization block
  • dynamical systems theory
  • epilepsy
  • neural mass model
  • refractory status epilepticus

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