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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Differential Effects of Nasal Inflammation and Odor Deprivation on Layer-Specific Degeneration of the Mouse Olfactory Bulb

Sanae Hasegawa-Ishii, Fumiaki Imamura, Shin Nagayama, Makiko Murata and Atsuyoshi Shimada
eNeuro 27 March 2020, 7 (2) ENEURO.0403-19.2020; https://doi.org/10.1523/ENEURO.0403-19.2020
Sanae Hasegawa-Ishii
1Pathology Research Team, Faculty of Health Sciences, Kyorin University, Mitaka, Tokyo 181-8612, Japan
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Fumiaki Imamura
2Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033-0850
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Shin Nagayama
3Department of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 00730-1501
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Makiko Murata
1Pathology Research Team, Faculty of Health Sciences, Kyorin University, Mitaka, Tokyo 181-8612, Japan
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Atsuyoshi Shimada
1Pathology Research Team, Faculty of Health Sciences, Kyorin University, Mitaka, Tokyo 181-8612, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0403-19.2020
PubMed 
32220858
Published By 
Society for Neuroscience
History 
  • Received October 3, 2019
  • Revision received March 8, 2020
  • Accepted March 16, 2020
  • Published online March 27, 2020.
Copyright & Usage 
Copyright © 2020 Hasegawa-Ishii et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sanae Hasegawa-Ishii1,
  2. Fumiaki Imamura2,
  3. Shin Nagayama3,
  4. Makiko Murata1 and
  5. Atsuyoshi Shimada1
  1. 1Pathology Research Team, Faculty of Health Sciences, Kyorin University, Mitaka, Tokyo 181-8612, Japan
  2. 2Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033-0850
  3. 3Department of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX 00730-1501
  1. Correspondence should be addressed to Sanae Hasegawa-Ishii at sanae_ishii{at}ks.kyorin-u.ac.jp or Fumiaki Imamura at fui1{at}psu.edu.
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Author contributions

  1. Author contributions: S.H.-I. and F.I. designed research; S.H.-I. and M.M. performed research; S.H.-I. and M.M. contributed unpublished reagents/analytic tools; S.H.-I. and F.I. analyzed data; S.H.-I., F.I., S.N., and A.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This study was supported by the Grant-in-Aid for Scientific Research KAKENHI 18K07395 (to S.H.-I.), the National Institutes of Health Grant R01DC016307 (to F.I.), and a grant from Kyorin University.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    18K07395
  • NIH

    R01DC016307

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  • You are viewing the most recent version of this article.
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Total65768321743
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Differential Effects of Nasal Inflammation and Odor Deprivation on Layer-Specific Degeneration of the Mouse Olfactory Bulb
Sanae Hasegawa-Ishii, Fumiaki Imamura, Shin Nagayama, Makiko Murata, Atsuyoshi Shimada
eNeuro 27 March 2020, 7 (2) ENEURO.0403-19.2020; DOI: 10.1523/ENEURO.0403-19.2020

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Differential Effects of Nasal Inflammation and Odor Deprivation on Layer-Specific Degeneration of the Mouse Olfactory Bulb
Sanae Hasegawa-Ishii, Fumiaki Imamura, Shin Nagayama, Makiko Murata, Atsuyoshi Shimada
eNeuro 27 March 2020, 7 (2) ENEURO.0403-19.2020; DOI: 10.1523/ENEURO.0403-19.2020
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Keywords

  • atrophy
  • nasal inflammation
  • neuro-inflammation
  • odor deprivation
  • olfactory bulb
  • olfactory system

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