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Research ArticleResearch Article: New Research, Neuronal Excitability

Propagating Activity in Neocortex, Mediated by Gap Junctions and Modulated by Extracellular Potassium

Christoforos A. Papasavvas, R. Ryley Parrish and Andrew J. Trevelyan
eNeuro 25 February 2020, 7 (2) ENEURO.0387-19.2020; https://doi.org/10.1523/ENEURO.0387-19.2020
Christoforos A. Papasavvas
Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
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  • ORCID record for Christoforos A. Papasavvas
R. Ryley Parrish
Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
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Andrew J. Trevelyan
Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0387-19.2020
PubMed 
32098762
Published By 
Society for Neuroscience
History 
  • Received September 25, 2019
  • Revision received January 2, 2020
  • Accepted January 27, 2020
  • Published online February 25, 2020.
Copyright & Usage 
Copyright © 2020 Papasavvas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christoforos A. Papasavvas,
  2. R. Ryley Parrish and
  3. Andrew J. Trevelyan
  1. Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
  1. Correspondence should be addressed to Andrew J. Trevelyan at andrew.trevelyan{at}ncl.ac.uk.
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Author contributions

  1. Author contributions: C.A.P. and A.J.T. designed research; C.A.P. and R.R.P. performed research; C.A.P., R.R.P., and A.J.T. analyzed data; C.A.P. and A.J.T. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by project grants from Epilepsy Research UK (Grant P1504) and Medical Research Council (UK) (Grants MR/J013250/1 and MR/R005427/1). A.J.T. was the recipient of a Schaefer Scholarship from Columbia University. C.A.P. was supported by a Wellcome Trust PhD Studentship (099755/Z/12/Z). We would like also to acknowledge the technical assistance provided by Neela Codadu and Eike Joest, when we were starting this project.

Funding

  • Wellcome Trust (Wellcome)

    099755/Z/12/Z
  • Medical Research Council (MRC)

    MR/J013250/1; MR/R005427/1
  • Epilepsy Research UK (ERUK)

    P1504

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 25, 2020).

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Article usage: February 2020 to January 2026

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Feb 2020117023
Mar 2020594151168
May 20204139022
Jun 20202321416
Jul 2020105521
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Jan 20215668
Feb 202155912
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Apr 20214728
May 202197212
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Jul 202126327
Aug 20215688
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May 202515112
Jun 20259689
Jul 202559620
Aug 202576318
Sep 2025411619
Oct 2025128324
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Total 202566948186
Jan 20266898
Total 20266898
Total108054311120
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eneuro: 7 (2)
eNeuro
Vol. 7, Issue 2
March/April 2020
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Propagating Activity in Neocortex, Mediated by Gap Junctions and Modulated by Extracellular Potassium
Christoforos A. Papasavvas, R. Ryley Parrish, Andrew J. Trevelyan
eNeuro 25 February 2020, 7 (2) ENEURO.0387-19.2020; DOI: 10.1523/ENEURO.0387-19.2020

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Propagating Activity in Neocortex, Mediated by Gap Junctions and Modulated by Extracellular Potassium
Christoforos A. Papasavvas, R. Ryley Parrish, Andrew J. Trevelyan
eNeuro 25 February 2020, 7 (2) ENEURO.0387-19.2020; DOI: 10.1523/ENEURO.0387-19.2020
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Keywords

  • electrotonic
  • excitability
  • gap junction
  • parvalbumin
  • potassium
  • seizure

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