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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption

Alexey Ostroumov, Ruthie E. Wittenberg, Blake A. Kimmey, Madison B. Taormina, William M. Holden, Albert T. McHugh and John A. Dani
eNeuro 26 February 2020, 7 (2) ENEURO.0348-19.2020; https://doi.org/10.1523/ENEURO.0348-19.2020
Alexey Ostroumov
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Ruthie E. Wittenberg
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Blake A. Kimmey
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Madison B. Taormina
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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William M. Holden
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Albert T. McHugh
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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John A. Dani
Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0348-19.2020
PubMed 
32102779
Published By 
Society for Neuroscience
History 
  • Received August 29, 2019
  • Revision received January 20, 2020
  • Accepted February 16, 2020
  • Published online February 26, 2020.
Copyright & Usage 
Copyright © 2020 Ostroumov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexey Ostroumov,
  2. Ruthie E. Wittenberg,
  3. Blake A. Kimmey,
  4. Madison B. Taormina,
  5. William M. Holden,
  6. Albert T. McHugh and
  7. John A. Dani
  1. Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
  1. Correspondence should be addressed to Alexey Ostroumov at ao711{at}georgetown.edu or John A. Dani at johndani{at}pennmedicine.upenn.edu.
  • A. Ostroumov’s present address: Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007.

View Full Text

Author contributions

  1. Author contributions: A.O. and J.A.D. designed research; A.O., R.E.W., B.A.K., M.B.T., W.M.H., and A.T.M. performed research; A.O., R.E.W., B.A.K., M.B.T., W.M.H., and A.T.M. analyzed data; A.O., R.E.W., B.A.K., M.B.T., W.M.H., A.T.M., and J.A.D. wrote the paper.

  • A. Ostroumov’s present address: Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from the National Institutes of Health DA009411, NS021229, and AA026267 (J.A.D.). A.O. was supported by DA048134 (NIH). B.A.K was supported by AA026766 (NIH). This work also was supported by the generous award from the Chernowitz Medical Research Foundation.

Funding

  • NINDS

    NS021229
  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    AA026267; AA026766
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA009411; DA048134
  • Chernowitz Mediacal Research Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 26, 2020).

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Total153668011756
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Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption
Alexey Ostroumov, Ruthie E. Wittenberg, Blake A. Kimmey, Madison B. Taormina, William M. Holden, Albert T. McHugh, John A. Dani
eNeuro 26 February 2020, 7 (2) ENEURO.0348-19.2020; DOI: 10.1523/ENEURO.0348-19.2020

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Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption
Alexey Ostroumov, Ruthie E. Wittenberg, Blake A. Kimmey, Madison B. Taormina, William M. Holden, Albert T. McHugh, John A. Dani
eNeuro 26 February 2020, 7 (2) ENEURO.0348-19.2020; DOI: 10.1523/ENEURO.0348-19.2020
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Keywords

  • benzodiazepines
  • chloride
  • dopamine
  • GABA
  • KCC2
  • mesolimbic

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