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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Sex-Specific Differences in Motor-Unit Remodeling in a Mouse Model of ALS

Éric Martineau, Adriana Di Polo, Christine Vande Velde and Richard Robitaille
eNeuro 7 February 2020, 7 (1) ENEURO.0388-19.2020; https://doi.org/10.1523/ENEURO.0388-19.2020
Éric Martineau
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada
2Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec H3T 1C5, Canada
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Adriana Di Polo
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada
3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec H2X 0A9, Canada
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Christine Vande Velde
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada
3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec H2X 0A9, Canada
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Richard Robitaille
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada
4Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, H3C 1J7, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0388-19.2020
PubMed 
32033983
Published By 
Society for Neuroscience
History 
  • Received September 24, 2019
  • Revision received January 20, 2020
  • Accepted January 27, 2020
  • Published online February 7, 2020.
Copyright & Usage 
Copyright © 2020 Martineau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Éric Martineau1,2,
  2. Adriana Di Polo1,3,
  3. Christine Vande Velde1,3 and
  4. Richard Robitaille1,4
  1. 1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada
  2. 2Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec H3T 1C5, Canada
  3. 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec H2X 0A9, Canada
  4. 4Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, H3C 1J7, Canada
  1. Correspondence should be addressed to Éric Martineau at eric.martineau.3{at}umontreal.ca.
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Author contributions

  1. Author contributions: É.M. and R.R. designed research; É.M. performed research; A.D.P. and C.V.V. contributed unpublished reagents/analytic tools; É.M. analyzed data; É.M., A.D.P., C.V.V., and R.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Canadian Institutes for Health Research Grants MOP-111070 (to R.R.) and PJT-376483 (to A.D.P.), Robert Packard Center for ALS Research (R.R.), Canadian Foundation of Innovation (R.R., C.V.V.), ALS Society of Canada (C.V.V.), Muscular Dystrophy Association (C.V.V.), and an infrastructure grant from the Fonds Recherche Québec-Santé Leader Opportunity Fund to the Groupe de Recherche sur le Système Nerveux Central. C.V.V. is an FRQS Senior Research Scholar. A.D.P. is a Canada Research Chair in Glaucoma and Age-Related Neurodegeneration. É.M. held a doctoral studentship from the ALS Society of Canada.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    MOP-111070; PJT-376483
  • Robert Packard Center for ALS Research

  • Canadian Foundation of Innovation

  • Muscular Dystrophy Association (MDA)

  • ALS Society of Canada (ALS Canada)

  • Fonds de Recherche du Québec - Santé (FRQS)

  • Canada Research Chairs (Chaires de recherche du Canada)

    Glaucoma and Age-Related Neurodegeneration

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 07, 2020).

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Total135654711569
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Sex-Specific Differences in Motor-Unit Remodeling in a Mouse Model of ALS
Éric Martineau, Adriana Di Polo, Christine Vande Velde, Richard Robitaille
eNeuro 7 February 2020, 7 (1) ENEURO.0388-19.2020; DOI: 10.1523/ENEURO.0388-19.2020

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Sex-Specific Differences in Motor-Unit Remodeling in a Mouse Model of ALS
Éric Martineau, Adriana Di Polo, Christine Vande Velde, Richard Robitaille
eNeuro 7 February 2020, 7 (1) ENEURO.0388-19.2020; DOI: 10.1523/ENEURO.0388-19.2020
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Keywords

  • amyotrophic lateral sclerosis
  • motor-unit
  • neuromuscular junction
  • reinnervation
  • sex-specific differences
  • superoxide dismutase

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