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Research ArticleResearch Article: Confirmation, Disorders of the Nervous System

Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model

Elizabeth A. McCullagh, Shani Poleg, Nathaniel T. Greene, Molly M. Huntsman, Daniel J. Tollin and Achim Klug
eNeuro 17 January 2020, 7 (1) ENEURO.0300-19.2019; https://doi.org/10.1523/ENEURO.0300-19.2019
Elizabeth A. McCullagh
1Department of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045
4Department of Integrative Biology, Oklahoma State University, Stillwater, Oklahoma 74074
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  • ORCID record for Elizabeth A. McCullagh
Shani Poleg
1Department of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045
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Nathaniel T. Greene
2Department of Otolaryngology, University of Colorado Anschutz, Aurora, Colorado 80045
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Molly M. Huntsman
3Departments of Pediatrics and Pharmaceutical Sciences, University of Colorado Anschutz, Aurora, Colorado 80045
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Daniel J. Tollin
1Department of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045
2Department of Otolaryngology, University of Colorado Anschutz, Aurora, Colorado 80045
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Achim Klug
1Department of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0300-19.2019
PubMed 
31953317
Published By 
Society for Neuroscience
History 
  • Received July 31, 2019
  • Revision received December 1, 2019
  • Accepted December 20, 2019
  • Published online January 17, 2020.
Copyright & Usage 
Copyright © 2020 McCullagh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elizabeth A. McCullagh1,4,*,
  2. Shani Poleg1,*,
  3. Nathaniel T. Greene2,
  4. Molly M. Huntsman3,
  5. Daniel J. Tollin1,2 and
  6. Achim Klug1
  1. 1Department of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045
  2. 2Department of Otolaryngology, University of Colorado Anschutz, Aurora, Colorado 80045
  3. 3Departments of Pediatrics and Pharmaceutical Sciences, University of Colorado Anschutz, Aurora, Colorado 80045
  4. 4Department of Integrative Biology, Oklahoma State University, Stillwater, Oklahoma 74074
  1. Correspondence should be addressed to Elizabeth A. McCullagh at Elizabeth.mccullagh{at}okstate.edu.
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Author contributions

  1. Author contributions: E.A.M., N.T.G., D.J.T., and A.K. designed research; E.A.M. and S.P. performed research; E.A.M., S.P., and N.T.G. analyzed data; E.A.M., S.P., N.T.G., M.M.H., D.J.T., and A.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Supported in part by National Institutes of Health Grant R01-DC-017924 (A.K. and D.J.T.). E.A.M. was funded by the FRAXA Research Foundation and National Institutes of Health Grant 3T32-DC-012280-05S1.

  • ↵* E.A.M. and S.P. are co-first authors.

Funding

  • FRAXA Research Foundation

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    DC017924; 3T32DC012280-05S1

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 17, 2020).

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Total 202661567128
Total157852011515
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eneuro: 7 (1)
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Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model
Elizabeth A. McCullagh, Shani Poleg, Nathaniel T. Greene, Molly M. Huntsman, Daniel J. Tollin, Achim Klug
eNeuro 17 January 2020, 7 (1) ENEURO.0300-19.2019; DOI: 10.1523/ENEURO.0300-19.2019

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Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model
Elizabeth A. McCullagh, Shani Poleg, Nathaniel T. Greene, Molly M. Huntsman, Daniel J. Tollin, Achim Klug
eNeuro 17 January 2020, 7 (1) ENEURO.0300-19.2019; DOI: 10.1523/ENEURO.0300-19.2019
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Keywords

  • acoustic startle response
  • binaural hearing
  • fragile X syndrome
  • prepulse inhibition
  • spatial acuity

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